Mechanisms and molecules: What are the treatment targets for primary biliary cholangitis?

Marlyn J. Mayo – 12 February 2022 – Treatment of primary biliary cholangitis (PBC) with ursodeoxycholic acid (UDCA) is not always sufficient to prevent progression to hepatic decompensation and/or need for liver transplant. Adjuvant therapy with obeticholic acid may provide additional biochemical improvements in some patients, but it is not well‐tolerated by patients with significant itch or advanced cirrhosis. Thus, new and creative approaches to treating patients with PBC are important to identify.

Assessment of human leukocyte antigen matching algorithm PIRCHE‐II on liver transplantation outcomes

Gautam Kok, Monique M. A. Verstegen, Roderick H. J. Houwen, Edward E. S. Nieuwenhuis, Herold J. Metselaar, Wojciech G. Polak, Luc J. W. Laan, Eric Spierings, Caroline M. den Hoed, Sabine A. Fuchs – 12 February 2022 – For liver transplantations, human leukocyte antigen (HLA) matching is not routinely performed because observed effects have been inconsistent. Nevertheless, long‐term liver transplantation outcomes remain suboptimal.

FGF4 protects the liver from nonalcoholic fatty liver disease by activating the AMP‐activated protein kinase–Caspase 6 signal axis

Lintao Song, Luyao Wang, Yushu Hou, Jie Zhou, Chuchu Chen, Xianxi Ye, Wenliya Dong, Huan Gao, Yi Liu, Guanting Qiao, Tongtong Pan, Qiong Chen, Yu Cao, Fengjiao Hu, Zhiheng Rao, Yajing Chen, Yu Han, Minghua Zheng, Yongde Luo, Xiaokun Li, Yongping Chen, Zhifeng Huang – 11 February 2022

Effect of Omega‐3 Polyunsaturated Fatty Acids on Lipid Metabolism in Patients With Metabolic Syndrome and NAFLD

Václav Šmíd, Karel Dvořák, Petr Šedivý, Vít Kosek, Martin Leníček, Monika Dezortová, Jana Hajšlová, Milan Hájek, Libor Vítek, Kamila Bechyňská, Radan Brůha – 10 February 2022 – Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease. n‐3 polyunsaturated fatty acids (n‐3‐PUFAs) have been reported to ameliorate the progression of NAFLD in experimental studies; however, clinical trials have yielded contradictory results.

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