Direct Conversion of Human Endothelial Cells Into Liver Cancer‐Forming Cells Using Nonintegrative Episomal Vectors

Takeshi Goya, Kenichi Horisawa, Miyako Udono, Yasuyuki Ohkawa, Yoshihiro Ogawa, Sayaka Sekiya, Atsushi Suzuki – 26 February 2022 – Liver cancer is an aggressive cancer associated with a poor prognosis. Development of therapeutic strategies for liver cancer requires fundamental research using suitable experimental models. Recent progress in direct reprogramming technology has enabled the generation of many types of cells that are difficult to obtain and provide a cellular resource in experimental models of human diseases.

Use of neural network models to predict liver transplantation waitlist mortality

Shunji Nagai, Anubhav Reddy Nallabasannagari, Dilip Moonka, Madhu Reddiboina, Sirisha Yeddula, Toshihiro Kitajima, Iman Francis, Marwan Abouljoud – 26 February 2022 – Current liver transplantation (LT) organ allocation relies on Model for End‐Stage Liver Disease–sodium scores to predict mortality in patients awaiting LT. This study aims to develop neural network (NN) models that more accurately predict LT waitlist mortality.

Preoperative portal vein recanalization–transjugular intrahepatic portosystemic shunt for chronic obliterative portal vein thrombosis: Outcomes following liver transplantation

Abhinav Talwar, Jeffrey Varghese, Gabriel M. Knight, Nitin Katariya, Juan‐Carlos Caicedo, Zach Dietch, Daniel Borja‐Cacho, Daniella Ladner, Derrick Christopher, Talia Baker, Michael Abecassis, Samdeep Mouli, Kush Desai, Ahsun Riaz, Bart Thornburg, Riad Salem – 26 February 2022 – High‐grade portal vein thrombosis (PVT) is often considered to be a technically challenging scenario for liver transplantation (LT) and in some centers a relative contraindication.

Ethnicity, disease severity, and survival in Canadian patients with primary biliary cholangitis

Surain B. Roberts, Gideon M. Hirschfield, Lawrence J. Worobetz, Catherine Vincent, Jennifer A. Flemming, Angela Cheung, Karim Qumosani, Mark Swain, Dusanka Grbic, Hin Hin Ko, Kevork Peltekian, Nazia Selzner, Lusine Abrahamyan, Bishoi Aziz, Ellina Lytvyak, Kattleya Tirona, Aliya F. Gulamhusein, Harry L. A. Janssen, Aldo J. Montano‐Loza, Andrew L. Mason, Bettina E. Hansen, the Canadian Network for Autoimmune Liver Disease (CaNAL) – 25 February 2022

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Xinrong Zhang, Grace Lai‐Hung Wong, Terry Cheuk‐Fung Yip, Vincent Wai‐Sun Wong – 25 February 2022

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