LiverLearning®: Fundamentals of Liver Disease - Alcohol-associated Liver Disease

DESCRIPTION The overall goal is to improve patient care by increasing learner competence and confidence in assessment and management of patients with alcohol-associated liver disease. The current content is geared towards increasing learner performance in therapeutic options and on-treatment management strategies for patients. Patient outcomes will be improved because of the improvements in more providers understanding these key components in the management and care of patients with alcohol-associated liver disease.

A review of racial, socioeconomic, and geographic disparities in pediatric liver transplantation

Noelle H. Ebel, Jennifer C. Lai, John C. Bucuvalas, Sharad I. Wadhwani – 20 February 2022 – Equity is a core principle in both pediatrics and solid organ transplantation. Health inequities, specifically across race, socioeconomic position, or geography, reflect a moral failure. Ethical principles of prudential life span, maximin principle, and fair innings argue for allocation priority to children related to the number of life years gained, equal access to transplant, and equal opportunity for ideal posttransplant outcomes.

Changes in serum hepatitis B surface and e antigen, interferon‐inducible protein 10, and aminotransferase levels during combination therapy of immune‐tolerant chronic hepatitis B

Robert Perrillo, Hsing‐Hua S. Lin, Kathleen B. Schwarz, Philip Rosenthal, Mauricio Lisker‐Melman, Raymond T. Chung, Ludmila Prokunina‐Olsson, Gavin Cloherty, Jordan Feld, for the Hepatitis B Research Network (HBRN) – 20 February 2022

Status 1B designation does not adequately prioritize children with acute‐on‐chronic liver failure for liver transplantation

Leslie Mataya, Therese Bittermann, William O. Quarshie, Heather Griffis, Vijay Srinivasan, Elizabeth B. Rand, Alicia M. Alcamo – 20 February 2022 – Acute‐on‐chronic liver failure (ACLF) is an acute decompensation of chronic liver disease leading to multiorgan failure and mortality. The objective of this study was to evaluate characteristics and outcomes of children with ACLF who are at the highest priority for liver transplantation (LT) on the United Network for Organ Sharing (UNOS) database—listed as status 1B.

Hypoxia‐driven immunosuppression by Treg and type‐2 conventional dendritic cells in HCC

Sheena Suthen, Chun Jye Lim, Phuong H. D. Nguyen, Charles‐Antoine Dutertre, Hannah L. H. Lai, Martin Wasser, Camillus Chua, Tony K. H. Lim, Wei Qiang Leow, Tracy Jiezhen Loh, Wei Keat Wan, Yin Huei Pang, Gwyneth Soon, Peng Chung Cheow, Juinn Huar Kam, Shridhar Iyer, Alfred Kow, Wai Leong Tam, Timothy W. H. Shuen, Han Chong Toh, Yock Young Dan, Glenn K. Bonney, Chung Yip Chan, Alexander Chung, Brian K. P. Goh, Weiwei Zhai, Florent Ginhoux, Pierce K. H. Chow, Salvatore Albani, Valerie Chew – 19 February 2022

Immunoglobulin M: A Neglected Serum Biomarker in Treatment‐Naive Primary Biliary Cholangitis With Normal Alkaline Phosphatase

Dawei Ding, Guoyun Xuan, Yinan Hu, Jiahao Yu, Yansheng Liu, Guanya Guo, Shuoyi Ma, Fangfang Yang, Siyuan Tian, Gang Ma, Ling Chen, Xinmin Zhou, Yulong Shang, Ying Han – 18 February 2022 – The diagnosis of primary biliary cholangitis (PBC) in patients with seropositive anti‐mitochondrial antibody (AMA) but normal alkaline phosphatase (ALP) depends on a liver biopsy. We aimed to reveal potential serum biomarkers that could suggest the necessity of a liver biopsy in such patients. Retrospective analysis was performed.

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