Grégory Merlen, Valérie‐Ann Raymond, Shamir Cassim, Pascal Lapierre, Marc Bilodeau – 21 January 2019 – Liver ischemia/reperfusion injury (IRI) is an important cause of liver damage especially early after liver transplantation, following liver resection, and in other clinical situations. Using rat experimental models, we identified oxaloacetate (OAA) as a key metabolite able to protect hepatocytes from hypoxia and IRI. In vitro screening of metabolic intermediates beneficial for hepatocyte survival under hypoxia was performed by measures of cell death and injury.

Li‐Ling Wu, Wei‐Hao Peng, Hui‐Lin Wu, Shi‐Chuen Miaw, Shiou‐Hwei Yeh, Hung‐Chih Yang, Pei‐Hsuan Liao, Jing‐Shan Lin, Yan‐Rong Chen, Yen‐Tien Hong, Hurng‐Yi Wang, Pei‐Jer Chen, Ding‐Shinn Chen – 19 January 2019 – To understand the mechanism(s) of age‐dependent outcomes of hepatitis B virus (HBV) infection in humans, we previously established an age‐related HBV mouse model in which 6‐week‐old (N6W) C3H/HeN mice exhibited virus tolerance whereas 12‐week‐old (N12W) counterparts presented virus clearance.

Kathy M. Nilles, Josh Levitsky – 19 January 2019

Kristian Harms, Gunter Flemming – 19 January 2019

Michael Trauner, Aliya Gulamhusein, Bilal Hameed, Stephen Caldwell, Mitchell L. Shiffman, Charles Landis, Bertus Eksteen, Kosh Agarwal, Andrew Muir, Simon Rushbrook, Xiaomin Lu, Jun Xu, Jen‐Chieh Chuang, Andrew N. Billin, Georgia Li, Chuhan Chung, G. Mani Subramanian, Robert P. Myers, Christopher L. Bowlus, Kris V. Kowdley – 19 January 2019 – Primary sclerosing cholangitis (PSC) represents a major unmet medical need.

Salvatore Piano, Marta Tonon, Paolo Angeli – 18 January 2019

Nicholas Russo, Arun Jesudian, Nicole T. Shen, Robert S. Brown, Akiko Sugiyama, Hayley T. Nicholls, Joseph F. Pisa, Tibor I. Krisko, Russell Rosenblatt, Zaid H. Tafesh, Brett E. Fortune, Omar Mousa, Harmeet Malhi, Robert E. Schwartz, Vikas Gupta, Tasha B. Kulai, Harmeet Malhi – 18 January 2019

Ton Lisman – 18 January 2019

Ebbe Billmann Thorgersen, Andreas Barratt‐Due, Håkon Haugaa, Morten Harboe, Søren Erik Pischke, Per H. Nilsson, Tom Eirik Mollnes – 17 January 2019 – The liver is both an immunologically complex and a privileged organ. The innate immune system is a central player, in which the complement system emerges as a pivotal part of liver homeostasis, immune responses, and crosstalk with other effector systems in both innate and adaptive immunity. The liver produces the majority of the complement proteins and is the home of important immune cells such as Kupffer cells.

Adrian M. Di Bisceglie – 17 January 2019