Yi Zheng, Hua Qu, Xin Xiong, Yuren Wang, Xiufei Liu, Linlin Zhang, Xiaoyu Liao, Qian Liao, Zheng Sun, Qin Ouyang, Gangyi Yang, Zhiming Zhu, Jing Xu, Hongting Zheng – 17 January 2019 – Mitochondrial glycerol 3‐phosphate dehydrogenase (mGPDH) is an integral component of the respiratory chain, and recent studies have suggested that it plays an important role in hepatic glucose homeostasis. However, its function in hepatic lipid metabolism is unclear. Here, we identified a role for mGPDH in nonalcoholic fatty liver disease (NAFLD).

Katharina Schwarzkopf, Sabrina Rüschenbaum, Samarpita Barat, Chengcong Cai, Marcus M. Mücke, Daniel Fitting, Andreas Weigert, Bernhard Brüne, Stefan Zeuzem, Christoph Welsch, Christian M. Lange – 17 January 2019 – Interleukin‐22 (IL‐22) has context‐dependent hepatoprotective or adverse properties in vitro and in animal models. IL‐22 binding protein (IL‐22BP) is a soluble inhibitor of IL‐22 signaling. The role of IL‐22 and IL‐22BP in patients with acute‐on‐chronic liver failure (ACLF) is unclear.

Ebbe Billmann Thorgersen, Andreas Barratt‐Due, Håkon Haugaa, Morten Harboe, Søren Erik Pischke, Per H. Nilsson, Tom Eirik Mollnes – 17 January 2019 – The liver is both an immunologically complex and a privileged organ. The innate immune system is a central player, in which the complement system emerges as a pivotal part of liver homeostasis, immune responses, and crosstalk with other effector systems in both innate and adaptive immunity. The liver produces the majority of the complement proteins and is the home of important immune cells such as Kupffer cells.

Jingjing Cai, Xiao‐Jing Zhang, Hongliang Li – 17 January 2019 – Inflammation and metabolic dysfunction are hallmarks of nonalcoholic steatohepatitis (NASH), which is one of the fastest‐growing liver diseases worldwide. Emerging evidence indicates that innate immune mechanisms are pivotal drivers of inflammation and other pathological manifestations observed in NASH, such as hepatosteatosis, insulin resistance (IR), and fibrosis.

Jingjing Cai, Xiao‐Jing Zhang, Hongliang Li – 17 January 2019 – Inflammation and metabolic dysfunction are hallmarks of nonalcoholic steatohepatitis (NASH), which is one of the fastest‐growing liver diseases worldwide. Emerging evidence indicates that innate immune mechanisms are pivotal drivers of inflammation and other pathological manifestations observed in NASH, such as hepatosteatosis, insulin resistance (IR), and fibrosis.

Ebbe Billmann Thorgersen, Andreas Barratt‐Due, Håkon Haugaa, Morten Harboe, Søren Erik Pischke, Per H. Nilsson, Tom Eirik Mollnes – 17 January 2019 – The liver is both an immunologically complex and a privileged organ. The innate immune system is a central player, in which the complement system emerges as a pivotal part of liver homeostasis, immune responses, and crosstalk with other effector systems in both innate and adaptive immunity. The liver produces the majority of the complement proteins and is the home of important immune cells such as Kupffer cells.

Gyongyi Szabo, Patrick S. Kamath, Vijay H. Shah, Mark Thursz, Philippe Mathurin – 15 January 2019 – A joint meeting of the European Association for the Study of the Liver (EASL) and the American Association for the Study of Liver Diseases (AASLD) was held in London on September 30 and October 1, 2017. The goals of the meeting were to identify areas of broad agreement and disagreement, develop consensus, and determine future directions to ultimately reduce the burden, morbidity, and mortality of alcohol‐related liver disease (previously termed alcoholic liver disease).

Gyongyi Szabo, Patrick S. Kamath, Vijay H. Shah, Mark Thursz, Philippe Mathurin – 15 January 2019 – A joint meeting of the European Association for the Study of the Liver (EASL) and the American Association for the Study of Liver Diseases (AASLD) was held in London on September 30 and October 1, 2017. The goals of the meeting were to identify areas of broad agreement and disagreement, develop consensus, and determine future directions to ultimately reduce the burden, morbidity, and mortality of alcohol‐related liver disease (previously termed alcoholic liver disease).

Mauro Panteghini, Ferruccio Ceriotti – 14 January 2019

Hui Chen, Feng Gao, Mian He, Xiao Fan Ding, Aikha M. Wong, Siu Ching Sze, Allen C. Yu, Tingting Sun, Anthony W‐H. Chan, Xin Wang, Nathalie Wong – 13 January 2019 – Alternative splicing (AS) allows generation of cell type–specific mRNA transcripts and contributes to hallmarks of cancer. Genome‐wide analysis for AS in human hepatocellular carcinoma (HCC), however, is limited. We sought to obtain a comprehensive AS landscape in HCC and define tumor‐associated variants.