Hui Chen, Feng Gao, Mian He, Xiao Fan Ding, Aikha M. Wong, Siu Ching Sze, Allen C. Yu, Tingting Sun, Anthony W‐H. Chan, Xin Wang, Nathalie Wong – 13 January 2019 – Alternative splicing (AS) allows generation of cell type–specific mRNA transcripts and contributes to hallmarks of cancer. Genome‐wide analysis for AS in human hepatocellular carcinoma (HCC), however, is limited. We sought to obtain a comprehensive AS landscape in HCC and define tumor‐associated variants.

Jan Hinrich Bräsen, Young‐Seon Mederacke, Jessica Schmitz, Kateryna Diahovets, Abedalrazag Khalifa, Björn Hartleben, Fermín Person, Thorsten Wiech, Eric Steenbergen, Anika Großhennig, Michael P. Manns, Roland Schmitt, Ingmar Mederacke – 11 January 2019 – Impairment of renal function often occurs in patients with liver disease. Hepatorenal syndrome is a significant cause of acute kidney injury (AKI) in patients with cirrhosis (HRS‐AKI, type 1). Causes of non‐HRS‐AKI include cholemic nephropathy (CN), a disease that is characterized by intratubular bile casts and tubular injury.

Catelyn Coyle, Anne C. Moorman, Tyler Bartholomew, Gary Klein, Helena Kwakwa, Shruti H. Mehta, Deborah Holtzman – 11 January 2019 – Improving care and treatment for persons infected with hepatitis C virus (HCV) can reduce HCV‐related morbidity and mortality. Our primary objective was to examine the HCV care continuum among patients receiving care at five federally qualified health centers (FQHCs) in Philadelphia, PA, where a testing and linkage to care program had been established.

Jan Hinrich Bräsen, Young‐Seon Mederacke, Jessica Schmitz, Kateryna Diahovets, Abedalrazag Khalifa, Björn Hartleben, Fermín Person, Thorsten Wiech, Eric Steenbergen, Anika Großhennig, Michael P. Manns, Roland Schmitt, Ingmar Mederacke – 11 January 2019 – Impairment of renal function often occurs in patients with liver disease. Hepatorenal syndrome is a significant cause of acute kidney injury (AKI) in patients with cirrhosis (HRS‐AKI, type 1). Causes of non‐HRS‐AKI include cholemic nephropathy (CN), a disease that is characterized by intratubular bile casts and tubular injury.

Naveed Z. Janjua, Maryam Darvishian, Stanley Wong, Amanda Yu, Carmine Rossi, Alnoor Ramji, Eric M. Yoshida, Zahid A. Butt, Hasina Samji, Mei Chong, Nuria Chapinal, Darrel Cook, Maria Alvarez, Mark Tyndall, Mel Krajden, the British Columbia Hepatitis Testers Cohort Team – 10 January 2019 – We evaluated the effectiveness of ledipasvir/sofosbuvir (LDV/SOF) in treating hepatitis C virus (HCV) genotype 1 and SOF/velpatasvir (SOF/VEL) for all genotypes among people who inject drugs (PWID) and those not injecting drugs and who were on or off opioid agonist therapy (OAT).

Maria Hukkinen, Jouko Lohi, Päivi Heikkilä, Reetta Kivisaari, Timo Jahnukainen, Hannu Jalanko, Mikko P. Pakarinen – 9 January 2019 – We investigated noninvasive follow‐up markers for histologic liver fibrosis and portal hypertension (PH) in patients with biliary atresia after successful portoenterostomy (PE). Among children with bilirubin <20 µmol/L after PE (n = 39), Metavir fibrosis stage was evaluated at PE and in follow‐up protocol liver biopsies (n = 83). PH was defined as endoscopically confirmed esophageal varices or thrombocytopenia associated with splenomegaly.

Benjamin Goeppert, Reka Toth, Stephan Singer, Thomas Albrecht, Daniel B. Lipka, Pavlo Lutsik, David Brocks, Marion Baehr, Oliver Muecke, Yassen Assenov, Lei Gu, Volker Endris, Albrecht Stenzinger, Arianeb Mehrabi, Peter Schirmacher, Christoph Plass, Dieter Weichenhan, Stephanie Roessler – 7 January 2019 – Intrahepatic cholangiocarcinoma (iCCA) is the second most common primary liver cancer. It is defined by cholangiocytic differentiation and has poor prognosis. Recently, epigenetic processes have been shown to play an important role in cholangiocarcinogenesis.

7 January 2019

Nadim Mahmud, David E. Kaplan, Tamar H. Taddei, David S. Goldberg – 7 January 2019 – The term acute‐on‐chronic liver failure (ACLF) is intended to identify patients with chronic liver disease who develop rapid deterioration of liver function and high short‐term mortality after an acute insult. The two prominent definitions (European Association for the Study of the Liver [EASL] and Asian Pacific Association for the Study of the Liver [APASL]) differ, and existing literature applies to narrow patient groups.

Marieke Heerkens, Suzanne Dedden, Hubertina Scheepers, Pieter Van Paassen, Ad Masclee, Christine de Die‐Smulders, Steven W.M. Olde Damink, Frank G. Schaap, Peter Jansen, Ger Koek, Ulrich Beuers, Jef Verbeek – 7 January 2019