Minmin Liu, Lian Zhang, Hongtao Li, Toshinori Hinoue, Wanding Zhou, Hitoshi Ohtani, Anthony El‐Khoueiry, John Daniels, Casey O'Connell, Tanya B. Dorff, Qianjin Lu, Daniel J. Weisenberger, Gangning Liang – 18 May 2018 – There is an urgent need to develop more effective therapies for hepatocellular carcinoma (HCC) because of its aggressiveness. Guadecitabine (SGI‐110) is a second‐generation DNA methyltransferase inhibitor (DNMTi), which is currently in clinical trials for HCC and shows greater stability and performance over first‐generation DNMTis.

Min Lian, Qixia Wang, Xiang Jiang, Jun Zhang, Yiran Wei, Yanmei Li, Bo Li, Weihua Chen, Haiyan Zhang, Qi Miao, Yanshen Peng, Xiao Xiao, Li Sheng, Weici Zhang, Jingyuan Fang, Ruqi Tang, M. Eric Gershwin, Xiong Ma – 18 May 2018 – The primary function of myeloid‐derived suppressor cells (MDSCs) is reflected in their immune modulatory role in several immune‐mediated diseases. In immunoglobulin G4 (IgG4)–related disease (IgG4‐RD), it has been hypothesized that there are selective regulatory defects that lead to a T helper 2 (Th2) bias immune response.

Alina M. Allen, Holly K. Houten, Lindsey R. Sangaralingham, Jayant A. Talwalkar, Rozalina G. McCoy – 18 May 2018 – The prevalence of nonalcoholic fatty liver disease (NAFLD) is increasing. The health care burden resulting from the multidisciplinary management of this complex disease is unknown. We assessed the total health care cost and resource utilization associated with a new NAFLD diagnosis, compared with controls with similar comorbidities.

Teresa L. Wright, K. Rajender Reddy, Thomas D. Boyer – 12 May 2018

10 May 2018

Kyung Chul Yoon, Sanghee Song, Eun‐Kyoung Jwa, Sanghoon Lee, Jong Man Kim, Ok‐kyoung Kim, Suk Kyun Hong, Nam‐Joon Yi, Kwang‐Woong Lee, Myoung Soo Kim, Shin Hwang, Kyung‐Suk Suh, Suk‐Koo Lee – 10 May 2018 – Split‐liver transplantation (SLT) should be cautiously considered because the right trisection (RTS) graft can be a marginal graft in adult recipients. Herein, we analyzed the outcomes of RTS‐SLT in Korea, where >75% of adult liver transplantations are performed with living donor liver transplantation.

Peng Sun, Yue‐Xin Lu, Daqing Cheng, Kuo Zhang, Jilin Zheng, Yupeng Liu, Xiaozhan Wang, Yu‐Feng Yuan, Yi‐Da Tang – 9 May 2018 – Sterile inflammation is an essential factor causing hepatic ischemia/reperfusion (I/R) injury. As a critical regulator of inflammation, the role of monocyte chemoattractant protein‐induced protein 1 (MCPIP1) in hepatic I/R injury remains undetermined. In this study, we discovered that MCPIP1 downregulation was associated with hepatic I/R injury in liver transplant patients and a mouse model.

Kristina Behnke, Yuan Zhuang, Haifeng C. Xu, Balamurugan Sundaram, Maria Reich, Prashant V. Shinde, Jun Huang, Nastaran Fazel Modares, Alexei V. Tumanov, Robin Polz, Jürgen Scheller, Carl F. Ware, Klaus Pfeffer, Verena Keitel, Dieter Häussinger, Aleksandra A. Pandyra, Karl S. Lang, Philipp A. Lang – 9 May 2018 – The liver has an extraordinary capacity to regenerate through activation of key molecular pathways. However, central regulators controlling liver regeneration remain insufficiently studied.

Ahmer M. Hameed, Jerome M. Laurence, Vincent W. T. Lam, Henry C. Pleass, Wayne J. Hawthorne – 9 May 2018

Kazi Abdus Salam, Richard Y. Wang, Teresa Grandinetti, Valeria Giorgi, Harvey J. Alter, Robert D. Allison – 9 May 2018 – Erythrocytes bind circulating immune complexes (ICs) and facilitate IC clearance from the circulation. Chronic hepatitis C virus (HCV) infection is associated with IC‐related disorders. In this study, we investigated the kinetics and mechanism of HCV and HCV‐IC binding to and dissociation from erythrocytes. Cell culture‐produced HCV was mixed with erythrocytes from healthy blood donors, and erythrocyte‐associated virus particles were quantified.