Preemptive Activation of the Integrated Stress Response Protects Mice From Diet‐Induced Obesity and Insulin Resistance by Fibroblast Growth Factor 21 Induction

Xu Xu, Christopher Krumm, Jae‐Seon So, Curtis J. Bare, Corey Holman, Jesper Gromada, David E. Cohen, Ann‐Hwee Lee – 26 April 2018 – Integrated stress response (ISR) is a signaling system in which phosphorylation of eukaryotic translation initiation factor 2α (eIF2α) by stress‐specific kinases and subsequent activation of activation transcription factor (ATF) 4 help restore cellular homeostasis following exposure to environmental stresses.

“Normal” Creatinine Levels Predict Persistent Kidney Injury and Waitlist Mortality in Outpatients With Cirrhosis

Giuseppe Cullaro, Meyeon Park, Jennifer C. Lai – 26 April 2018 – Acute kidney injury (AKI) is a critical determinant of outcomes in hospitalized patients with cirrhosis, but little is known of the impact of AKI in the outpatient setting. We analyzed 385 adult outpatients with cirrhosis listed for liver transplant at a single center; excluded were those with severe hepatic encephalopathy, with hepatocellular carcinoma, or on hemodialysis.

Fatigue, Pain, and Other Physical Symptoms of Living Liver Donors in the Adult‐to‐Adult Living Donor Liver Transplantation Cohort Study

Zeeshan Butt, Andrea F. DiMartini, Qian Liu, Mary Ann Simpson, Abigail R. Smith, Jarcy Zee, Brenda W. Gillespie, Susan Holtzman, Daniela Ladner, Kim Olthoff, Robert A. Fisher, Silvia Hafliger, Chris E. Freise, Mercedes Susan Mandell, Averell H. Sherker, Mary Amanda Dew – 26 April 2018 – Little is known about living liver donors' perceptions of their physical well‐being following the procedure. We collected data on donor fatigue, pain, and other relevant physical outcomes as part of the prospective, multicenter Adult‐to‐Adult Living Donor Liver Transplantation Cohort Study consortium.

Interleukin 2 Promotes Hepatic Regulatory T Cell Responses and Protects From Biliary Fibrosis in Murine Sclerosing Cholangitis

Amy E. Taylor, Alexandra N. Carey, Ramesh Kudira, Celine S. Lages, Tiffany Shi, Simon Lam, Rebekah Karns, Julia Simmons, Kumar Shanmukhappa, Maha Almanan, Claire A. Chougnet, Alexander G. Miethke – 26 April 2018 – In the multidrug resistance protein 2 (Mdr2)‐/‐ mouse model, low phospholipid bile instigates biliary epithelial injury, sterile inflammation, and fibrosis, thereby recapitulating disease mechanisms implicated in biliary atresia (BA) and primary sclerosing cholangitis.

Ubiquitin‐Specific Peptidase 10 (USP10) Inhibits Hepatic Steatosis, Insulin Resistance, and Inflammation Through Sirt6

Pengcheng Luo, Cong Qin, Lihua Zhu, Chun Fang, Yan Zhang, Hai Zhang, Fei Pei, Song Tian, Xue‐Yong Zhu, Jun Gong, Qing Mao, Chengcheng Xiao, Yang Su, Haizhou Zheng, Tao Xu, Jingxiao Lu, Jie Zhang – 26 April 2018 – Nonalcoholic fatty liver disease (NAFLD) is characterized by hepatic steatosis, insulin resistance and inflammation, and the pathogenic mechanism of NAFLD is poorly understood. Ubiquitin‐specific peptidase 10 (USP10), a member of the ubiquitin‐specific protease family, is involved in environmental stress responses, tumor growth, inflammation, and cellular metabolism.

Protein phosphatase 1 regulatory subunit 3B gene variation protects against hepatic fat accumulation and fibrosis in individuals at high risk of nonalcoholic fatty liver disease

Paola Dongiovanni, Marica Meroni, Rosellina M. Mancina, Guido Baselli, Raffaela Rametta, Serena Pelusi, Ville Männistö, Anna L. Fracanzani, Sara Badiali, Luca Miele, Stefania Grimaudo, Salvatore Petta, Elisabetta Bugianesi, Giorgio Soardo, Silvia Fargion, Jussi Pihlajamäki, Stefano Romeo, Luca Valenti – 25 April 2018 – Nonalcoholic fatty liver disease (NAFLD) is a major cause of liver damage and has a strong genetic component.

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