Tissue Repair in the Mouse Liver Following Acute Carbon Tetrachloride Depends on Injury‐Induced Wnt/β‐Catenin Signaling

Ludan Zhao, Yinhua Jin, Katie Donahue, Margaret Tsui, Matt Fish, Catriona Y. Logan, Bruce Wang, Roel Nusse – 14 February 2019 – In the liver, Wnt/β‐catenin signaling is involved in regulating zonation and hepatocyte proliferation during homeostasis. We examined Wnt gene expression and signaling after injury, and we show by in situ hybridization that Wnts are activated by acute carbon tetrachloride (CCl4) toxicity. Following injury, peri‐injury hepatocytes become Wnt‐responsive, expressing the Wnt target gene axis inhibition protein 2 (Axin2).

The Yield and Safety of Screening Colonoscopy in Patients Evaluated for Liver Transplantation

Rosalie C. Oey, Laurelle van Tilburg, Nicole S. Erler, Herold J. Metselaar, Manon C.W. Spaander, Henk R. van Buuren, Robert A. de Man – 14 February 2019 – Colorectal cancer (CRC) screening with colonoscopy is commonly used in patients who are candidates for liver transplantation. We initiated this study to define the risk‐benefit ratio of performing screening colonoscopy in this population. A retrospective observational study of all consecutive patients undergoing colonoscopy during pre–liver transplantation screening between 2004 and 2017 was conducted.

Recessive Mutations in KIF12 Cause High Gamma‐Glutamyltransferase Cholestasis

Aysel Ünlüsoy Aksu, Subhash K. Das, Carol Nelson‐Williams, Dhanpat Jain, Ferda Özbay Hoşnut, Gülseren Evirgen Şahin, Richard P. Lifton, Silvia Vilarinho – 13 February 2019 – Undiagnosed liver disease remains an unmet medical need in pediatric hepatology, including children with high gamma‐glutamyltransferase (GGT) cholestasis. Here, we report whole‐exome sequencing of germline DNA from 2 unrelated children, both offspring of consanguineous union, with neonatal cholestasis and high GGT of unclear etiology.

Current Knowledge, Barriers to Implementation, and Future Directions in Palliative Care for End‐Stage Liver Disease

Zachary P. Fricker, Marina Serper – 13 February 2019 – End‐stage liver disease (ESLD) is associated with a high degree of morbidity and mortality as well as symptom burden. Despite this, the rate of consultation with palliative care (PC) providers remains low, and invasive procedures near the end of life are commonplace. Studies show that involvement of PC providers improves patient satisfaction, and evidence from other chronic diseases demonstrates reduced costs of care and potentially increased survival.

Hepatic Interferon Regulatory Factor 6 Alleviates Liver Steatosis and Metabolic Disorder by Transcriptionally Suppressing Peroxisome Proliferator‐Activated Receptor γ in Mice

Jingjing Tong, Cui‐Juan Han, Jia‐Zhen Zhang, Wen‐Zhi He, Guo‐Jun Zhao, Xu Cheng, Lei Zhang, Ke‐Qiong Deng, Ye Liu, Hui‐Fen Fan, Song Tian, Jingjing Cai, Zan Huang, Zhi‐Gang She, Peng Zhang, Hongliang Li – 12 February 2019 – Nonalcoholic fatty liver disease (NAFLD) has become a worldwide epidemic. A large and growing unmet therapeutic need has inspired numerous studies in the field.

Evolving Trends in Liver Transplant for Metabolic Liver Disease in the United States

Patrick J. McKiernan, Armando Ganoza, James E. Squires, Robert H. Squires, Jerry Vockley, George Mazariegos, Kyle Soltys, Qing Sun, Rakesh Sindhi – 12 February 2019 – Indications for liver transplantation (LT) in metabolic disease are evolving. We reviewed the US experience with primary LT for metabolic disease in the Scientific Registry for Transplant Recipients (October 1987 to June 2017) to determine the following: temporal changes in indications, longterm outcomes, and factors predicting survival.

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