Hawwa Alao, Maggie Cam, Chithra Keembiyehetty, Fang Zhang, Elisavet Serti, Daniel Suarez, Heiyoung Park, Nicolaas H. Fourie, Elizabeth C. Wright, Wendy A. Henderson, Qisheng Li, T. Jake Liang, Barbara Rehermann, Marc G. Ghany – 27 April 2018 – Hepatitis C virus (HCV) infection induces interferon (IFN)‐stimulated genes (ISGs) and downstream innate immune responses. This study investigated whether baseline and on‐treatment differences in these responses predict response versus virological breakthrough during therapy with direct‐acting antivirals (DAAs).

Shilpa Chokshi – 27 April 2018

Qing Liang, Zeyuan Liu, Chao Zhu, Bin Wang, Xiaoke Liu, Yanan Yang, Xue Lv, Haiyu Mu, Kejia Wang – 27 April 2018 – T lymphocytes synergize with the cellular immune system to promote hepatocyte regeneration. The T‐cell receptor (TCR) immune repertoire is closely associated with the host immune response and regenerative proliferation. High‐throughput sequencing of TCR provides deep insight into monitoring the immune microenvironment. Here, we aimed to determine the role of the TCRβ immune repertoire in liver regeneration (LR).

Jingjing Jiao, Gordon P. Watt, Heather L. Stevenson, Tiffany L. Calderone, Susan P. Fisher‐Hoch, Yuanqing Ye, Xifeng Wu, John M. Vierling, Laura Beretta – 27 April 2018 – Telomerase reverse transcriptase (TERT) mutation is the most frequent genetic alteration in hepatocellular carcinoma (HCC). Our aims were to investigate whether TERT mutations can be detected in circulating cell‐free DNA (cfDNA) of patients with HCC and/or cirrhosis and characterize clinical parameters associated with these mutations.

Andrea Schlegel, Paolo Muiesan – 27 April 2018

Yin Yin, Xiaoliang Xu, Junwei Tang, Wenjie Zhang, Guangyan Zhangyuan, Jie Ji, Lei Deng, Shuai Lu, Han Zhuo, Beicheng Sun – 27 April 2018 – Cluster of differentiation 97 (CD97) is a member of the epidermal growth factor seven‐transmembrane family belonging to the class B G protein–coupled receptors (GPCRs). The protein affects tumor aggressiveness through its cellular ligand CD55 stimulation and exhibits adhesive properties. Studies have demonstrated the involvement of CD97 in dedifferentiation, migration, invasiveness, and metastasis of tumors.

Sumera Rizvi, Gregory J. Gores – 27 April 2018

Myriam Dao, Dalila Habès, Jean‐Luc Taupin, Charlotte Mussini, Marie‐José Redon, Caroline Suberbielle, Emmanuel Jacquemin, Emmanuel Gonzales, Catherine Guettier – 27 April 2018 – This study aims to define the morphological profile associated with the presence of donor‐specific antibodies (DSAs) and/or C4d immunostaining in ABO‐identical or compatible pediatric liver grafts. Ten‐year protocol liver graft biopsies performed at 131.3 ± 15.3 months after transplantation in 53 pediatric liver graft recipients were reviewed.

Laurence Britton, Kim Bridle, Janske Reiling, Nishreen Santrampurwala, Leesa Wockner, Helena Ching, Katherine Stuart, V. Nathan Subramaniam, Gary Jeffrey, Tim St. Pierre, Michael House, Joel Gummer, Robert Trengove, John Olynyk, Darrell Crawford, Leon Adams – 27 April 2018 – Rodent and cell‐culture models support a role for iron‐related adipokine dysregulation and insulin resistance in the pathogenesis of nonalcoholic fatty liver disease (NAFLD); however, substantial human data are lacking.

Chang‐Jiang Yu, Qiu‐Shi Wang, Ming‐Ming Wu, Bin‐Lin Song, Chen Liang, Jie Lou, Liang‐Liang Tang, Xiao‐Di Yu, Na Niu, Xu Yang, Bao‐Long Zhang, Yao Qu, Yang Liu, Zhi‐Chao Dong, Zhi‐Ren Zhang – 27 April 2018 – There is no effective treatment method for nonalcoholic fatty liver disease (NAFLD), the most common liver disease. The exact mechanism underlying the pathogenesis of NAFLD remains to be elucidated.