Preemptive Activation of the Integrated Stress Response Protects Mice From Diet‐Induced Obesity and Insulin Resistance by Fibroblast Growth Factor 21 Induction
Xu Xu, Christopher Krumm, Jae‐Seon So, Curtis J. Bare, Corey Holman, Jesper Gromada, David E. Cohen, Ann‐Hwee Lee – 26 April 2018 – Integrated stress response (ISR) is a signaling system in which phosphorylation of eukaryotic translation initiation factor 2α (eIF2α) by stress‐specific kinases and subsequent activation of activation transcription factor (ATF) 4 help restore cellular homeostasis following exposure to environmental stresses.