Combined en bloc liver pancreas transplantation for children with CF

Kristin L. Mekeel, Max R. Langham, Regino Gonzalez‐Perralta, Alan Reed, Alan W. Hemming – 22 February 2007 – Cystic fibrosis (CF) is an inherited genetic defect in epithelial chloride transport that results a multisystem disease affecting the sweat glands and the pulmonary and digestive systems. Although pulmonary disease remains the primary cause of morbidity and mortality in these patients, up to 8% may develop focal biliary cirrhosis and portal hypertension. Liver transplantation is an accepted therapy for these patients.

Low risk of hepatitis B virus recurrence after withdrawal of long‐term hepatitis B immunoglobulin in patients receiving maintenance nucleos(t)ide analogue therapy

Stephen N. Wong, Chi‐Jen Chu, Chun‐Tao Wai, Terese Howell, Charles Moore, Robert J. Fontana, Anna S.F. Lok – 22 February 2007 – Hepatitis B virus (HBV) recurrence rates of 0‐16% had been reported in patients maintained on nucleoside analogues (NA) after hepatitis B immunoglobulin (HBIG) discontinuation after orthotopic liver transplantation (OLT). However, follow‐up in most studies was short. We aimed to determine the long‐term risk of HBV recurrence using this strategy.

A caspase inhibitor, IDN‐6556, ameliorates early hepatic injury in an ex vivo rat model of warm and cold ischemia

Niel C. Hoglen, Dean M. Anselmo, Masamichi Katori, Marian Kaldas, Xiu‐Da Shen, Karen L. Valentino, Charles Lassman, Ronald W. Busuttil, Jerzy W. Kupiec‐Weglinski, Douglas G. Farmer – 22 February 2007 – This study examined the efficacy of the caspase inhibitor, IDN‐6556, in a rat model of liver ischemia‐reperfusion injury. Livers from male Sprague‐Dawley rats were reperfused for 120 minutes after 24 hours of 4°C cold storage in University of Wisconsin solution.

Early immunological monitoring after pediatric liver transplantation: Cytokine immune deviation and graft acceptance in 40 recipients

Jérémie Gras, Grégoire Wieërs, Jean‐Luc Vaerman, Dinh Quang Truong, Etienne Sokal, Jean‐Bernard Otte, Béatrice Délépaut, Anne Cornet, Jean de Ville de Goyet, Dominique Latinne, Raymond Reding – 22 February 2007 – Cytokine deviation may be a factor contributing to graft acceptance. We analyze, in the context of liver transplantation, circulating cytokine levels and their mRNA precursors in liver biopsy samples to study a putative correlation with early immunologic outcome.

Expanded criteria for liver transplantation in patients with hepatocellular carcinoma: A report from the International Registry of Hepatic Tumors in Liver Transplantation

Nicholas Onaca, Gary L. Davis, Robert M. Goldstein, Linda W. Jennings, Göran B. Klintmalm – 22 February 2007 – Hepatocellular carcinoma (HCC) is a common indication for liver transplantation (LT). Currently, deceased donor LT is approved by the United Network for Organ Sharing for patients with HCC who meet the Milan criteria of a single tumor up to 5 cm or up to 3 tumors up to 3 cm as determined by imaging studies. We analyzed data in the International Registry of Hepatic Tumors in Liver Transplantation from 1,206 patients with HCC.

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