Christophe Bureau, Jean‐Marie Péron, Laurent Alric, Joséphine Morales, Jérǒme Sanchez, Karl Barange, Jean‐Louis Payen, Jean‐Pierre Vinel – 7 March 2007 – We report the results of adapting medical therapy to the monitoring of hemodynamic response in the prevention of a first variceal bleeding or rebleeding in patients with cirrhosis. Hepatic venous pressure gradient (HVPG) was measured before and after propranolol was initiated. The patients were considered responders if HVPG decreased below 12 mm Hg or at least 20% as compared with baseline value.

Ngee‐Chih Foo, Byung Y. Ahn, Xiaohong Ma, William Hyun, T. S. Benedict Yen – 7 March 2007 – Fibrosing cholestatic hepatitis (FCH) is a rapidly progressive form of viral hepatitis B that occurs in severely immunosuppressed patients. Pathologically, the liver in FCH is characterized by widespread hepatocyte vacuolization and apoptosis, which, in contrast to more common forms of hepatitis B, is only rarely associated with significant inflammation.

Paulette Bioulac‐Sage, Hervé Trillaud, Christophe Laurent, Charles Balabaud, Claude Degott – 7 March 2007

Adrian Reuben – 7 March 2007

Ulrich Bienzle, Matthias Günther, Ruth Neuhaus, Pierre Vandepapeliere, Jens Vollmar, Andreas Lun, Peter Neuhaus – 7 March 2007 – Patients who undergo transplantation for hepatitis B virus (HBV)‐related diseases are treated indefinitely with hepatitis B hyperimmunoglobulin (HBIG) to prevent endogenous HBV reinfection of the graft. Active immunization with standard hepatitis B vaccines in these patients has recently been reported with conflicting results.

Laurie D. Deleve, Xiangdong Wang, Gary C. Kanel, Yoshiya Ito, Nancy W. Bethea, Margaret K. McCuskey, Zoltan A. Tokes, Jeffrey Tsai, Robert S. McCuskey – 7 March 2007 – This study examined the role of decreased nitric oxide (NO) in the microcirculatory obstruction of hepatic sinusoidal obstruction syndrome (SOS). SOS was induced in rats with monocrotaline. Monocrotaline caused hepatic vein NO to decrease by 30% at 24 hours and by 70% at 72 hours; this decrease persisted throughout late SOS.

Scott K. Fung, Anna S. F. Lok – 7 March 2007

Shiou‐Hwei Yeh, Ming‐Wei Lin, Shu‐Fen Lu, Dai‐Chen Wu, Shih‐Feng Tsai, Ching‐Yi Tsai, Ming‐Yang Lai, Hey‐Chi Hsu, Ding‐Shinn Chen, Pei‐Jer Chen – 7 March 2007 – Allelic loss of chromosome 4q is one of the most frequent genetic aberrations found in human hepatocellular carcinoma (HCC) and suggests the presence of putative tumor suppressor genes within this region. To precisely define the region containing these tumor suppressor genes for further positional cloning, we tried a detailed deletion mapping strategy in 149 HCCs by using 49 microsatellite markers covering 4q12 ≈ 25.

David Durantel, Sandra Carrouée‐Durantel, Bettina Werle‐Lapostolle, Marie‐Noëlle Brunelle, Christian Pichoud, Christian Trépo, Fabien Zoulim – 7 March 2007 – Resistance of hepatitis B virus (HBV) to antivirals has become a major clinical problem. Our objective was to develop a new method for the cloning of naturally occurring HBV genomes and a phenotypic assay capable of assessing HBV drug susceptibility and DNA synthesis capacity in vitro.

7 March 2007