Addition of adenosine monophosphate‐activated protein kinase activators to University of Wisconsin solution: A way of protecting rat steatotic livers

Ismail Ben Mosbah, Marta Massip‐Salcedo, Izabel Fernández‐Monteiro, Carme Xaus, Ramon Bartrons, Olivier Boillot, Joan Roselló‐Catafau, Carmen Peralta – 22 February 2007 – This study investigates how the addition of trimetazidine (TMZ) and aminoimidazole‐4‐carboxamide ribonucleoside (AICAR) to University of Wisconsin (UW) solution protects steatotic livers. Steatotic and nonsteatotic livers were preserved for 24 hours at 4°C in UW and UW with TMZ and AICAR (separately or in combination) and then perfused ex vivo for 2 hours at 37°C.

Early noncardiogenic pulmonary edema and the use of PEEP and prone ventilation after emergency liver transplantation

E. Sykes, J. F. Cosgrove, I. D. Nesbitt, C. B. O'Suilleabhain – 22 February 2007 – Noncardiogenic pulmonary edema in liver transplant recipients is usually secondary to TRALI (transfusion related acute lung injury) or liver ischemic‐reperfusion injury. If persistent, the resultant hypoxemia is associated with increased ventilator days, prolonged length of stay (intensive care and hospital) and increased 28‐day mortality.

Orthotopic liver or multivisceral transplantation as treatment of metastatic neuroendocrine tumors

Michael Olausson, Styrbjörn Friman, Gustaf Herlenius, Christian Cahlin, Ola Nilsson, Svante Jansson, Bo Wängberg, Håkan Ahlman – 22 February 2007 – Liver transplantation can be a therapeutic option for individual patients with neuroendocrine tumors metastatic only to the liver. In this consecutive series of 15 patients (5 multivisceral and 10 orthotopic liver transplantations) with well‐differentiated carcinoids, or endocrine pancreatic tumors, we allowed higher proliferation rate (Ki67 <10%), large tumor burden, and higher age than previous studies.

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