Núria Roglans, Laia Vilà, Mireia Farré, Marta Alegret, Rosa María Sánchez, Manuel Vázquez‐Carrera, Juan Carlos Laguna – 26 February 2007 – Fructose makes up a significant proportion of energy intake in westernized diets; its increased consumption has paralleled the growing prevalence of obesity and metabolic syndrome over the past two decades. In the current study, we demonstrate that fructose administration (10% wt/vol) in the drinking water of rats reduces the trans‐activating and trans‐repressing activity of the hepatic peroxisome proliferator‐activated receptor α (PPARα).

Lars E. Schmidt, Fin Stolze Larsen – 26 February 2007 – The Model for End‐Stage Liver Disease (MELD) scoring system has been established as a reliable measure of short‐term mortality risk in patients with end‐stage chronic liver disease. The aim of this study was to evaluate the prognostic value of the MELD scoring as a predictor of fulminant hepatic failure (FHF) and death in patients with acetaminophen poisoning. Prospectively, serial measurements of the 3 MELD components—INR, bilirubin, and creatinine—were performed in 460 patients with acetaminophen‐induced liver injury.

Srinivasa Prasad, Radha K. Dhiman, Ajay Duseja, Yogesh K. Chawla, Arpita Sharma, Ritesh Agarwal – 26 February 2007 – Minimal hepatic encephalopathy (MHE) has a negative effect on patients' daily functioning. Thus far, no study has investigated the effect of treatment‐related improvement in cognitive functions on health‐related quality of life (HRQOL).

Luca Di Tommaso, Giada Franchi, Young Nyun Park, Barbara Fiamengo, Annarita Destro, Emanuela Morenghi, Marco Montorsi, Guido Torzilli, Maurizio Tommasini, Luigi Terracciano, Luigi Tornillo, Raffaella Vecchione, Massimo Roncalli – 26 February 2007 – Hepatocellular nodules in cirrhosis include regenerative (large regenerative, LRN) and dysplastic (low and high grade, LGDN and HGDN) nodules, early and grade 1 HCC (eHCC‐G1), and overt HCC. The differential diagnosis may be particularly difficult when lesions such as HGDN and eHCC‐G1 are involved.

Amalia Penna, Massimo Pilli, Alessandro Zerbini, Alessandra Orlandini, Sergio Mezzadri, Luca Sacchelli, Gabriele Missale, Carlo Ferrari – 26 February 2007 – The functional impairment of HCV‐specific T cell responses is believed to be an important determinant of HCV persistence, but the functional T cell defects of patients with chronic hepatitis C (CH‐C) are only partially defined. CD8 responses to HLA‐A2–restricted epitopes of HCV and other unrelated viruses were studied in 23 HLA‐A2–positive patients both ex vivo and after in vitro culture.

Paul J. Pockros, Lennox Jeffers, Nezam Afdhal, Zachary D. Goodman, David Nelson, Robert G. Gish, K. Rajender Reddy, Robert Reindollar, Maribel Rodriguez‐Torres, Sarah Sullivan, Lawrence M. Blatt, Sima Faris‐Young – 26 February 2007 – Interferon‐γ1b (IFN‐γ1b) is a pleiotropic cytokine that displays antifibrotic, antiviral, and antiproliferative activity.

Koko Bate Aborsangaya, Iga Dembinski, Suresh Khatkar, Martin Prince Alphonse, Peter Nickerson, Julia D. Rempel – 26 February 2007 – The host immune response is a critical determinant in viral infection outcome. Epidemiological studies indicate that North American indigenous peoples are more resistant to chronic HCV infection than other populations. Due to the prominence of IL‐10 in chronic HCV infection, we investigated the genetic tendency to produce IL‐10 in Caucasian (CA) and First Nation (FN) populations.

Evangelos Cholongitas, Laura Marelli, Andrew Kerry, Marco Senzolo, David W. Goodier, Devaki Nair, Michael Thomas, David Patch, Andrew K. Burroughs – 23 February 2007 – Bilirubin (Bil) interferes with creatinine (Cr) measurement. Different laboratory methods are used to overcome this problem. Model for end‐stage liver disease (MELD) scoring incorporates Cr and is used to prioritize patients for liver transplantation. Thus, MELD scores may vary with different Cr measurements influencing patients' priority.

Jessica Tan, Anna S.F. Lok – 22 February 2007

James D. Perkins – 22 February 2007