Addition of adenosine monophosphate‐activated protein kinase activators to University of Wisconsin solution: A way of protecting rat steatotic livers
Ismail Ben Mosbah, Marta Massip‐Salcedo, Izabel Fernández‐Monteiro, Carme Xaus, Ramon Bartrons, Olivier Boillot, Joan Roselló‐Catafau, Carmen Peralta – 22 February 2007 – This study investigates how the addition of trimetazidine (TMZ) and aminoimidazole‐4‐carboxamide ribonucleoside (AICAR) to University of Wisconsin (UW) solution protects steatotic livers. Steatotic and nonsteatotic livers were preserved for 24 hours at 4°C in UW and UW with TMZ and AICAR (separately or in combination) and then perfused ex vivo for 2 hours at 37°C.