Maid (GCIP) is involved in cell cycle control of hepatocytes

Eva Sonnenberg‐Riethmacher, Torsten Wüstefeld, Michaela Miehe, Christian Trautwein, Dieter Riethmacher – 26 January 2007 – The function of Maid (GCIP), a cyclinD‐binding helix‐loop‐helix protein, was analyzed by targeted disruption in mice. We show that Maid function is not required for normal embryonic development. However, older Maid‐deficient mice—in contrast to wild‐type controls—develop hepatocellular carcinomas. Therefore, we studied the role of Maid during cell cycle progression after partial hepatectomy (PH).

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