Early histologic changes in fibrosing cholestatic hepatitis C

Lisa R. Dixon, James M. Crawford – 4 January 2007 – Recurrent hepatitis C (RHCV) after liver transplantation is almost universal, and occasional patients will have an aggressive course characterized histologically by pericellular/sinusoidal fibrosis and cholestasis, known as fibrosing cholestatic hepatitis (FCH). The early stages and evolution of this disease have not been well characterized. A total of 77 liver biopsies performed for indication (nonprotocol) were evaluated for necroinflammation, rejection, cholestasis, and fibrosis.

Long‐term survival and predictors of relapse after orthotopic liver transplantation for alcoholic liver disease

Robert Pfitzmann, Jeannette Schwenzer, Nada Rayes, Daniel Seehofer, Ruth Neuhaus, Natascha C. Nüssler – 4 January 2007 – The relevance of sobriety for outcome after orthotopic liver transplantation (OLT) for alcoholic liver disease (ALD) is still discussed controversially. We conducted a retrospective analysis of 300 patients transplanted for ALD with regard to recurrent alcohol consumption, risk factors for drinking after OLT, and long‐term survival. The 300 patients underwent OLT for ALD between 1989 and 2002. Median follow‐up was 89 months.

Risk factors for new‐onset diabetes mellitus following liver transplantation and impact of hepatitis c infection : An observational multicenter study

Faouzi Saliba, Mohamed Lakehal, Georges‐Philippe Pageaux, Bruno Roche, Claire Vanlemmens, Christophe Duvoux, Jérôme Dumortier, Ephrem Salamé, Yvon Calmus, Didier Maugendre, Diapason Study Group – 27 December 2006 – New‐onset diabetes mellitus (NODM) remains a common complication of liver transplantation (LT). We studied incidence and risk factors in 211 French patients who had undergone a primary LT between 6 and 24 months previously. This is a cross‐sectional and retrospective multicenter study. Data were collected on consecutive patients at a single routine post‐LT consultation.

Effect of side and size of graft on surgical outcomes of adult‐to‐adult live donor liver transplantation

See Ching Chan, Sheung Tat Fan, Chung Mau Lo, Chi Leung Liu – 27 December 2006 – By virtue of size, the right liver graft has become the workhorse of adult‐to‐adult live donor liver transplantation (ALDLT). Although favorable results of left liver ALDLT have also been reported, a head‐to‐head comparison of these 2 graft types both containing the middle hepatic vein had not been made. In this study, we compared the outcomes of 29 right liver and 16 left liver ALDLTs of comparable graft weight to recipient estimated standard liver volume ratio (GW/ESLV, 36.9% and 36.4%, respectively).

Exploring the bidirectional interactions between human cytomegalovirus and hepatitis C virus replication after liver transplantation

Gaia Nebbia, Frank M. Mattes, Evangelos Cholongitas, Ana Garcia‐Diaz, Dimitrios N. Samonakis, Andrew K. Burroughs, Vincent C. Emery – 27 December 2006 – Recurrence of Hepatitis C (HCV) post‐liver transplantation (LT) is universal and its course is more aggressive than in immunocompetent individuals. Human cytomegalovirus (CMV) infection is a common post‐LT infection and has immunomodulatory effects that could adversely affect the outcome of HCV. To date, the effect of HCV replication on the dynamics of CMV have not been investigated.

Use of split‐liver allografts does not impair pediatric recipient growth

Alejandro Mejia, Neil Barshes, Glenn Halff, John Goss, W. Kenneth Washburn – 27 December 2006 – The use of split‐liver (SL) allografts continues to be an excellent option for many pediatric recipients. Patient and graft survival with this graft type are comparable to patient and graft survival with whole organ grafts. Quality‐of‐life issues, specifically growth, for SL recipients have not been compared to those of recipients of more conventional whole‐organ recipients. Pediatric recipients of SL and whole allografts at 2 institutions were identified.

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