Zeeshan Perveze, Mark W. Johnson, Raymond A. Rubin, Marty Sellers, Carlos Zayas, Jody L. Jones, Rosemary Cross, Kimberly Thomas, Bradley Butler, Roshan Shrestha – 27 December 2006 – Drug‐induced liver disease accounts for about 50% of acute or subacute liver failure in the United States. United Network of Organ Sharing (UNOS) data suggest 8%‐20% of liver transplantation in this country per year is for fulminant liver failure due to drugs.

Koichiro Hata, Rene Hany Tolba, Lai Wei, Benedict Marie Doorschodt, Reinhard Büttner, Yuzo Yamamoto, Thomas Minor – 27 December 2006 – Chronic shortage of donor organs has led to acceptance of steatotic livers as grafts, although there is a higher risk of primary graft dysfunction. We herein report the beneficial impact of Polysol, a newly developed preservation solution, on cold storage of steatotic rat livers. Dietary hepatic steatosis was induced in Wistar rats by 2‐day fasting and subsequent 3‐day re‐feeding with a fat‐free, carbohydrate‐rich diet.

Ekaterina Katenz, Florian Wolfgang Rudolf Vondran, Ruth Schwartlander, Gesine Pless, Xiaobing Gong, Xiandong Cheng, Peter Neuhaus, Igor Maximilian Sauer – 27 December 2006 – Problems with the limited availability of human hepatocytes for cell transplantation may be overcome by efficient cryopreservation techniques and formation of appropriate cell banking. In this study we investigated the effect of the disaccharide trehalose on the cryopreservation of human hepatocytes.

Norah A. Terrault, Mitchell L. Shiffman, Anna S.F. Lok, Sammy Saab, Lan Tong, Robert S. Brown, Gregory T. Everson, K. Rajender Reddy, Jeffrey H. Fair, Laura M. Kulik, Timothy L. Pruett, Leonard B.

Paul J. Thuluvath – 27 December 2006

Marina Berenguer, Ana Royuela, Javier Zamora – 27 December 2006 – A controversy exists over whether the outcome of a hepatitis C virus (HCV)‐infection‐related liver transplant differs based on the calcineurin inhibitor (CNI) used. We have performed a systematic review and a subsequent meta‐analysis evaluating tacrolimus (Tac)‐based vs. cyclosporine A‐based immunosuppression in HCV‐infected liver transplant recipients. Searches were conducted to locate randomized controlled trials comparing Tac vs. cyclosporine A.

Daisuke Morioka, Hiroto Egawa, Mureo Kasahara, Tomoyasu Jo, Seisuke Sakamoto, Yasuhiro Ogura, Hironori Haga, Yasutsugu Takada, Hiroshi Shimada, Koichi Tanaka – 27 December 2006 – Patient selection criteria of deceased donor liver transplantation for primary biliary cirrhosis (PBC) are almost completely established. The aim of this study was to establish selection criteria for both patients and donors of living donor liver transplantation (LDLT) for PBC.

27 December 2006

Wilfredo Polido, Lee Kang Hoe, Ng Kheng Siang, Tan Kai Chah – 27 December 2006 – Acute myocardial infarction is a tedious risk inherent in all major surgeries. Preoperative assessment has been directed mainly to assess its risk because it carries with it a very high mortality. Living donor liver transplantation has been subject to inquest not only because of the morbidity risk but also because of the mortality risk it carries to the live donor. We report a case of a 39‐year‐old donor who died of acute myocardial infarction following right‐lobe donor hepatectomy.

Dieter C. Broering, Jessica Walter, Xavier Rogiers – 27 December 2006 – The major limitation in adult‐to‐adult living donor liver transplantation (LDLT) is an adequate graft size with special regard to the safety of the donor. Only 20% of the evaluated donors are suitable to donate the right liver, depending mainly on the critical remnant liver volume. We report 2 cases of adult‐to‐adult LDLT using dual grafts. In the first case we implanted a left lateral lobe together with a left lobe; in the second case we used a left lateral and a right lobe.