Hepatic HNF4α deficiency induces periportal expression of glutamine synthetase and other pericentral enzymes

Vesna S. Stanulović, Irene Kyrmizi, Marianna Kruithof‐de Julio, Maarten Hoogenkamp, Jacqueline L. M. Vermeulen, Jan M. Ruijter, Iannis Talianidis, Theodorus B. M. Hakvoort, Wouter H. Lamers – 26 January 2007 – In liver, most genes are expressed with a porto‐central gradient. The transcription factor hepatic nuclear‐factor4α (HNF4α) is associated with 12% of the genes in adult liver, but its involvement in zonation of gene expression has not been investigated.

Activation of vascular adhesion protein‐1 on liver endothelium results in an NF‐κB–dependent increase in lymphocyte adhesion

Patricia F. Lalor, Phoebe Jun Sun, Chris J. Weston, Azucena Martin‐Santos, Michael J. O. Wakelam, David H. Adams – 26 January 2007 – Vascular adhesion protein‐1 (VAP‐1) is an adhesion molecule and amine oxidase that is expressed at high levels in the human liver. It promotes leukocyte adhesion to the liver in vivo and drives lymphocyte transmigration across hepatic sinusoidal endothelial cells in vitro.

The role of chrysin and the Ah receptor in induction of the human UGT1A1 gene in vitro and in transgenic UGT1 mice

Jessica A. Bonzo, Alain Bélanger, Robert H. Tukey – 26 January 2007 – The flavonoid chrysin is an important dietary substance and induces UGT1A1 protein expression in cell culture. As a representative of the class of dietary flavonoids, clinical investigations have been considered as a means of inducing hepatic UGT1A1 expression. We demonstrate the necessity of a xenobiotic response element (XRE) in support of chrysin induction of UGT1A1 in the human hepatoma cell line HepG2.

Activation of LXRs prevents bile acid toxicity and cholestasis in female mice

Hirdesh Uppal, Simrat P.S. Saini, Antonio Moschetta, Ying Mu, Jie Zhou, Haibiao Gong, Yonggong Zhai, Songrong Ren, George K. Michalopoulos, David J. Mangelsdorf, Wen Xie – 26 January 2007 – Liver X receptors (LXRs) have been identified as sterol sensors that regulate cholesterol and lipid homeostasis and macrophage functions. In this study, we found that LXRs also affect sensitivity to bile acid toxicity and cholestasis.

Temporary silastic mesh closure for adult liver transplantation: A safe alternative for the difficult abdomen

Mubeen A. Jafri, Amit D. Tevar, Mark Lucia, Thav Thambi‐Pillai, Andreas Karachristos, Leslie Trumbull, Joseph F. Buell, Mark J. Thomas, Michael J. Hanaway, E. Steve Woodle, Steven M. Rudich – 26 January 2007 – Primary fascial closure is often difficult after adult orthotopic liver transplantation (OLT), complicated by donor‐to‐recipient graft size mismatch, post‐reperfusion hepatic edema, coagulopathy, or intestinal edema. Attempts at closing the abdomen under these circumstances can cause increase in intra‐abdominal pressures, resulting in significant complications, including graft loss.

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