James D. Perkins – 22 February 2007

Michael Olausson, Styrbjörn Friman, Gustaf Herlenius, Christian Cahlin, Ola Nilsson, Svante Jansson, Bo Wängberg, Håkan Ahlman – 22 February 2007 – Liver transplantation can be a therapeutic option for individual patients with neuroendocrine tumors metastatic only to the liver. In this consecutive series of 15 patients (5 multivisceral and 10 orthotopic liver transplantations) with well‐differentiated carcinoids, or endocrine pancreatic tumors, we allowed higher proliferation rate (Ki67 <10%), large tumor burden, and higher age than previous studies.

E. Sykes, J. F. Cosgrove, I. D. Nesbitt, C. B. O'Suilleabhain – 22 February 2007 – Noncardiogenic pulmonary edema in liver transplant recipients is usually secondary to TRALI (transfusion related acute lung injury) or liver ischemic‐reperfusion injury. If persistent, the resultant hypoxemia is associated with increased ventilator days, prolonged length of stay (intensive care and hospital) and increased 28‐day mortality.

Ismail Ben Mosbah, Marta Massip‐Salcedo, Izabel Fernández‐Monteiro, Carme Xaus, Ramon Bartrons, Olivier Boillot, Joan Roselló‐Catafau, Carmen Peralta – 22 February 2007 – This study investigates how the addition of trimetazidine (TMZ) and aminoimidazole‐4‐carboxamide ribonucleoside (AICAR) to University of Wisconsin (UW) solution protects steatotic livers. Steatotic and nonsteatotic livers were preserved for 24 hours at 4°C in UW and UW with TMZ and AICAR (separately or in combination) and then perfused ex vivo for 2 hours at 37°C.

Jens Rosenau, Nazanin Hooman, Johannes Hadem, Kinan Rifai, Matthias J. Bahr, Gunnar Philipp, Hans L. Tillmann, Juergen Klempnauer, Christian P. Strassburg, Michael P. Manns – 22 February 2007 – Hepatitis B vaccination after liver transplantation for hepatitis B–related liver disease has been investigated as an alternative strategy to reinfection prophylaxis with hepatitis B immunoglobulin (HBIG) with conflicting results. In most studies, HBIG treatment was discontinued before vaccination.

Tanja Bauer, Matthias Günther, Ulrich Bienzle, Ruth Neuhaus, Wolfgang Jilg – 22 February 2007 – After liver transplantation for hepatitis‐B‐related diseases, patients currently receive lifelong treatment with hepatitis B immunoglobulin to prevent endogenous reinfection with hepatitis B virus (HBV). Active immunization with hepatitis B vaccine would be a preferable alternative; however, most attempts to immunize these patients with standard vaccine have failed.

Markus Selzner, Nazia Selzner, Wolfram Jochum, Rolf Graf, Pierre‐Alain Clavien – 22 February 2007 – Although livers exhibit only minimal morphologic changes with age, how older livers tolerate pathologic conditions such as normothermic ischemia is unknown. Young 6‐week‐old mice and old 60‐week‐old mice underwent 60 minutes of hepatic ischemia and various periods of reperfusion. Markers of hepatocyte injury, hepatic energy content, and mitochondrial function were determined.

Johannes Hadem, Volker Westerkamp, Christian Trautwein, Michael Winkler, Michael P. Manns, Carsten Hafer – 22 February 2007

Gerd Otto – 22 February 2007

Nicholas Onaca, Gary L. Davis, Robert M. Goldstein, Linda W. Jennings, Göran B. Klintmalm – 22 February 2007 – Hepatocellular carcinoma (HCC) is a common indication for liver transplantation (LT). Currently, deceased donor LT is approved by the United Network for Organ Sharing for patients with HCC who meet the Milan criteria of a single tumor up to 5 cm or up to 3 tumors up to 3 cm as determined by imaging studies. We analyzed data in the International Registry of Hepatic Tumors in Liver Transplantation from 1,206 patients with HCC.