The Exosome‐Associated Tetraspanin CD63 Contributes to the Efficient Assembly and Infectivity of the Hepatitis B Virus

Masashi Ninomiya, Jun Inoue, Eugene W. Krueger, Jing Chen, Hong Cao, Atsushi Masamune, Mark A. McNiven – 30 March 2021 – Currently, the hepatocellular trafficking pathways that are used by the hepatitis B virus (HBV) during viral infection and shedding are poorly defined. It is known that the HBV uses late endosomal and multivesicular body (MVB) compartments for assembly and release. The intraluminal vesicles (ILVs) generated within MVBs have also been implicated in the late synthesis stages of a variety of pathogenic viruses.

The Addition of C‐Reactive Protein and von Willebrand Factor to Model for End‐Stage Liver Disease‐Sodium Improves Prediction of Waitlist Mortality

Patrick Starlinger, Joseph C. Ahn, Aidan Mullan, Georg P. Gyoeri, David Pereyra, Roberto Alva‐Ruiz, Hubert Hackl, Thomas Reiberger, Michael Trauner, Jonas Santol, Benedikt Simbrunner, Mattias Mandorfer, Gabriela Berlakovich, Patrick S. Kamath, Julie Heimbach – 30 March 2021

External Validation of the VOCAL‐Penn Cirrhosis Surgical Risk Score in 2 Large, Independent Health Systems

Nadim Mahmud, Zachary Fricker, Sarjukumar Panchal, James D. Lewis, David S. Goldberg, David E. Kaplan – 30 March 2021 – Cirrhosis poses an increased risk of postoperative mortality, yet it remains challenging to accurately risk stratify patients in clinical practice. The VOCAL‐Penn cirrhosis surgical risk score was recently developed and internally validated in the national Veterans Affairs health system; however, to date this score has not been evaluated in independent cohorts.

The 2020 Nobel Prize for Medicine or Physiology for the Discovery of Hepatitis C Virus: A Triumph of Curiosity and Persistence

Marc G. Ghany, Anna S.F. Lok, Jules L. Dienstag, Stephen M. Feinstone, Jay H. Hoofnagle, T. Jake Liang, Leonard B. Seeff, David E. Cohen, Jorge A. Bezerra, Raymond T. Chung – 29 March 2021 – The 2020 Nobel Prize in Medicine or Physiology was awarded to Drs. Harvey Alter, Michael Houghton, and Charles Rice for their contributions to the discovery and characterization of the hepatitis C virus (HCV). Their achievements represent a remarkable triumph of biomedical science which allowed the development of curative therapy for HCV, that will save countless lives.

LiverLearning®: 2021 Webinar: Simultaneous Liver Kidney Transplant: How Did We Do With the New Criteria?

In this one hour on-demand webinar, we will discuss how we arrived at the new organ allocation schema for simultaneous liver kidney (SLK) transplants by UNOS in partnership with our Transplant Nephrologists and the effect this has had on dual organ allocation and outcomes of SLK transplantation.Ryutaro Hirose Ryutaro Hirose, MD is professor and vice chair of clinical operations and value for the Department of Surgery at the University of California, San Francisco. He is an active liver, kidney and pancreas transplant surgeon.

Risk of HCC With Hepatitis B Viremia Among HIV/HBV‐Coinfected Persons in North America

H. Nina Kim, Craig W. Newcomb, Dena M. Carbonari, Jason A. Roy, Jessie Torgersen, Keri N. Althoff, Mari M. Kitahata, K. Rajender Reddy, Joseph K. Lim, Michael J. Silverberg, Angel M. Mayor, Michael A. Horberg, Edward R. Cachay, Gregory D. Kirk, Jing Sun, Mark Hull, M. John Gill, Timothy R. Sterling, Jay R. Kostman, Marion G. Peters, Richard D. Moore, Marina B. Klein, Vincent Lo Re, for the North American AIDS Cohort Collaboration on Research, Design of IeDEA – 28 March 2021

Albumin in Advanced Liver Diseases: The Good and Bad of a Drug!

Rakesh Kumar Jagdish, Jaswinder Singh Maras, Shiv Kumar Sarin – 26 March 2021 – Human serum albumin is the most abundant plasma protein, and it regulates diverse body functions. In patients with advanced and decompensated cirrhosis, serum albumin levels are low because of a reduction in the hepatocyte mass due to disease per se and multiple therapeutic interventions.

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