Pharmacokinetics, Safety, and Efficacy of Glecaprevir/Pibrentasvir in Children With Chronic HCV: Part 2 of the DORA Study

Maureen M. Jonas, Susan Rhee, Deirdre A. Kelly, Antonio Del Valle‐Segarra, Cornelia Feiterna‐Sperling, Susan Gilmour, Regino P. Gonzalez‐Peralta, Loreto Hierro, Daniel H. Leung, Simon C. Ling, Yuri Lobzin, Steven Lobritto, Tatsuki Mizuochi, Michael R. Narkewicz, Vishakha Sabharwal, Jessica Wen, Hoi Kei Lon, John Marcinak, Andrew Topp, Rakesh Tripathi, Etienne Sokal – 1 April 2021

The Exosome‐Associated Tetraspanin CD63 Contributes to the Efficient Assembly and Infectivity of the Hepatitis B Virus

Masashi Ninomiya, Jun Inoue, Eugene W. Krueger, Jing Chen, Hong Cao, Atsushi Masamune, Mark A. McNiven – 30 March 2021 – Currently, the hepatocellular trafficking pathways that are used by the hepatitis B virus (HBV) during viral infection and shedding are poorly defined. It is known that the HBV uses late endosomal and multivesicular body (MVB) compartments for assembly and release. The intraluminal vesicles (ILVs) generated within MVBs have also been implicated in the late synthesis stages of a variety of pathogenic viruses.

Propensity Score–Matched Analysis of Posttransplant Outcomes in Living Donor Liver Transplantation for Older Adult Recipients

Abdul Rahman Hakeem, Rukhaiya Fathima, Hrishikesh Padmanaban, Kulaseharan Haribabu, Rajesh Rajalingam, Kumar Palaniappan, Dinesh Jothimani, Rathan Kanagavelu, Akila Rajakumar, Ilankumaran Kaliamoorthy, Mettu Srinivas Reddy, Mohamed Rela – 30 March 2021 – The impact of increasing recipient age on morbidity and mortality following living donor liver transplantation (LDLT) remains controversial. The study aims to analyze the impact of recipient age on outcomes following LDLT.

Reply

Toshihiro Kitajima, Dilip Moonka, Sirisha Yeddula, Kelly Collins, Michael Rizzari, Atsushi Yoshida, Marwan S. Abouljoud, Shunji Nagai – 30 March 2021

The Addition of C‐Reactive Protein and von Willebrand Factor to Model for End‐Stage Liver Disease‐Sodium Improves Prediction of Waitlist Mortality

Patrick Starlinger, Joseph C. Ahn, Aidan Mullan, Georg P. Gyoeri, David Pereyra, Roberto Alva‐Ruiz, Hubert Hackl, Thomas Reiberger, Michael Trauner, Jonas Santol, Benedikt Simbrunner, Mattias Mandorfer, Gabriela Berlakovich, Patrick S. Kamath, Julie Heimbach – 30 March 2021

External Validation of the VOCAL‐Penn Cirrhosis Surgical Risk Score in 2 Large, Independent Health Systems

Nadim Mahmud, Zachary Fricker, Sarjukumar Panchal, James D. Lewis, David S. Goldberg, David E. Kaplan – 30 March 2021 – Cirrhosis poses an increased risk of postoperative mortality, yet it remains challenging to accurately risk stratify patients in clinical practice. The VOCAL‐Penn cirrhosis surgical risk score was recently developed and internally validated in the national Veterans Affairs health system; however, to date this score has not been evaluated in independent cohorts.

The 2020 Nobel Prize for Medicine or Physiology for the Discovery of Hepatitis C Virus: A Triumph of Curiosity and Persistence

Marc G. Ghany, Anna S.F. Lok, Jules L. Dienstag, Stephen M. Feinstone, Jay H. Hoofnagle, T. Jake Liang, Leonard B. Seeff, David E. Cohen, Jorge A. Bezerra, Raymond T. Chung – 29 March 2021 – The 2020 Nobel Prize in Medicine or Physiology was awarded to Drs. Harvey Alter, Michael Houghton, and Charles Rice for their contributions to the discovery and characterization of the hepatitis C virus (HCV). Their achievements represent a remarkable triumph of biomedical science which allowed the development of curative therapy for HCV, that will save countless lives.

LiverLearning®: 2021 Webinar: Simultaneous Liver Kidney Transplant: How Did We Do With the New Criteria?

In this one hour on-demand webinar, we will discuss how we arrived at the new organ allocation schema for simultaneous liver kidney (SLK) transplants by UNOS in partnership with our Transplant Nephrologists and the effect this has had on dual organ allocation and outcomes of SLK transplantation.Ryutaro Hirose Ryutaro Hirose, MD is professor and vice chair of clinical operations and value for the Department of Surgery at the University of California, San Francisco. He is an active liver, kidney and pancreas transplant surgeon.

Subscribe to