Hepcidin Signaling in Health and Disease: Ironing Out the Details

Kris V. Kowdley, Eric M. Gochanour, Vinay Sundaram, Raj A. Shah, Priya Handa – 25 March 2021 – Hepcidin, a peptide hormone produced by hepatocytes, is the central regulator of systemic iron homeostasis through its interaction with ferroportin, the major cellular iron export protein. Hepcidin binding to ferroportin results in reduced iron export from macrophages and intestinal absorptive cells, leading to decreased serum iron levels. Hepcidin expression is influenced by several factors that include serum and liver iron stores, erythropoiesis, hypoxia, inflammation, and infection.

Genetic Determinants of Outcome in Intrahepatic Cholangiocarcinoma

Thomas Boerner, Esther Drill, Linda M. Pak, Bastien Nguyen, Carlie S. Sigel, Alexandre Doussot, Paul Shin, Debra A. Goldman, Mithat Gonen, Peter J. Allen, Vinod P. Balachandran, Andrea Cercek, James Harding, David B. Solit, Nikolaus Schultz, Ritika Kundra, Henry Walch, Michael I. D’Angelica, Ronald P. DeMatteo, Jeffrey Drebin, Nancy E. Kemeny, T. Peter Kingham, Amber L. Simpson, Jaclyn F. Hechtman, Efsevia Vakiani, Maeve A. Lowery, J.N.M. Ijzermans, S. Buettner, B. Groot Koerkamp, M. Doukas, Rohit Chandwani, William R. Jarnagin – 24 March 2021

Proteomic Profiling of Hepatocellular Adenomas Paves the Way to Diagnostic and Prognostic Approaches

Cyril Dourthe, Céline Julien, Sylvaine Di Tommaso, Jean‐William Dupuy, Nathalie Dugot‐Senant, Alexandre Brochard, Brigitte Le Bail, Jean‐Frédéric Blanc, Laurence Chiche, Charles Balabaud, Paulette Bioulac‐Sage, Frédéric Saltel, Anne‐Aurélie Raymond – 22 March 2021

Experimental Models of Liquid Biopsy in Hepatocellular Carcinoma Reveal Clone‐Dependent Release of Circulating Tumor DNA

Ismail Labgaa, Johann Felden, Amanda J. Craig, Sebastiao N. Martins‐Filho, Carlos Villacorta‐Martin, Nicolas Demartines, Olivier Dormond, Delia D’Avola, Augusto Villanueva – 22 March 2021 – Liquid biopsy, the molecular analysis of tumor components released into the bloodstream, has emerged as a noninvasive and resourceful means to access genomic information from cancers. Most data derived from translational studies showcase its numerous potential clinical applications.

Colonoscopy and Risk of Colorectal Cancer in Patients With Nonalcoholic Fatty Liver Disease: A Retrospective Territory‐Wide Cohort Study

Xinrong Zhang, Vincent Wai‐Sun Wong, Terry Cheuk‐Fung Yip, Yee‐Kit Tse, Lilian Yan Liang, Vicki Wing‐Ki Hui, Guan‐Lin Li, Henry Lik‐Yuen Chan, Grace Lai‐Hung Wong – 20 March 2021 – The benefit of colonoscopy and/or polypectomy for colorectal cancer (CRC) prevention in patients with nonalcoholic fatty liver disease (NAFLD) remains unclear. We aimed to estimate the incidence rate of CRC in patients with NAFLD who had and had not undergone colonoscopy.

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