Exosomes and MicroRNA‐223 at the Intersection of Inflammation and Fibrosis in NAFLD
Gyongyi Szabo – 15 March 2021
Radiofrequency Ablation Covering the Entire Tumor Blood Drainage Area Improves Survival in Hepatocellular Carcinoma
Masashi Hirooka, Yohei Koizumi, Takaaki Tanaka, Kotarou Sunago, Yoshiko Nakamura, Takao Watanabe, Osamu Yoshida, Yoshio Tokumoto, Masanori Abe, Yoichi Hiasa – 15 March 2021 – Hepatocellular carcinoma has been considered to disseminate through the tumor blood drainage area. To improve curation rates, treatment should cover this area as it may contain satellite lesions. This retrospective study aimed to investigate whether radiofrequency ablation (RFA) completely covering the blood drainage area can improve the overall and disease‐free survival.
Hematological and Genetic Markers in the Rational Approach to Patients With HCV Sustained Virological Response With or Without Persisting Cryoglobulinemic Vasculitis
Laura Gragnani, Serena Lorini, Silvia Marri, Umberto Basile, Veronica Santarlasci, Monica Monti, Francesco Madia, Luisa Petraccia, Cristina Stasi, Niccolò Marello, Cecilia Napodano, Francesco Annunziato, Anna Linda Zignego – 14 March 2021
Patterns of Inpatient Opioid Use and Related Adverse Events Among Patients With Cirrhosis: A Propensity‐Matched Analysis
Jessica B. Rubin, Jennifer C. Lai, Amy M. Shui, Samuel F. Hohmann, Andrew Auerbach – 14 March 2021 – Pain is common among patients with cirrhosis, yet managing pain in this population is challenging. Opioid analgesics are thought to be particularly high risk in patients with cirrhosis, and their use has been discouraged. We sought to understand patterns of opioid use among inpatients with cirrhosis and the risks of serious opioid‐related adverse events in this population.
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Jessica P. Woolfson, Binita M. Kamath, Vicky L. Ng – 13 March 2021
Beware of Portal Vein Thrombosis After Laparoscopic Sleeve Gastrectomy in Liver Transplant Recipients
Ken Liu, David Yeo, Michael Crawford, Simone I. Strasser, Geoffrey W. McCaughan – 12 March 2021
TNF‐α‐Induce Protein 8–Like 1 Inhibits Hepatic Steatosis, Inflammation, and Fibrosis by Suppressing Polyubiquitination of Apoptosis Signal–Regulating Kinase 1
Hong Wu, Xiaolei Xu, Ancheng Zheng, Weina Wang, Li Mei, Yue Chen, Shasha Sun, Liujun Jiang, Yutao Wu, Yijiang Zhou, Min Zheng, Qishan Chen – 12 March 2021
DNA Methylation Signatures Reveal the Diversity of Processes Remodeling Hepatocellular Carcinoma Methylomes
Léa Meunier, Théo Z. Hirsch, Stefano Caruso, Sandrine Imbeaud, Quentin Bayard, Amélie Roehrig, Gabrielle Couchy, Jean‐Charles Nault, Josep M. Llovet, Jean‐Frédéric Blanc, Julien Calderaro, Jessica Zucman‐Rossi, Eric Letouzé – 12 March 2021
Physiologic Reserve Assessment and Application in Clinical and Research Settings in Liver Transplantation
Rahima A. Bhanji, Kymberly D. Watt – 12 March 2021 – Physiologic reserve is an important prognostic indicator. Because of its complexity, no single test can measure an individual’s physiologic reserve. Frailty is the phenotypic expression of decreased reserve and portends poor prognosis. Both subjective and objective tools have been used to measure one or more components of physiologic reserve. Most of these tools appear to predict pretransplant mortality, but only some predict posttransplant survival.
Identification of Quantifiable Predictors of Relapse in Patients with Alcohol‐Associated Liver Disease
Nicole T. Shen, Alyson Kaplan, Khalid Fahoum, Elora Basu, Akhil Shenoy, Nabeel Wahid, Amanda Ivatorov, Joseph Pisa, Annaheta Salajegheh, Enad Dawod, Russell Rosenblatt, Brett Fortune, Monika Safford, Robert S. Brown – 12 March 2021 – Abstinence in patients with alcohol‐associated liver disease (ALD) reduces mortality. Most predictors of relapse are not quantifiable, preventing objective analysis of relapse risk and targeted intervention to improve clinical outcomes.