TNF‐α‐Induce Protein 8–Like 1 Inhibits Hepatic Steatosis, Inflammation, and Fibrosis by Suppressing Polyubiquitination of Apoptosis Signal–Regulating Kinase 1

Hong Wu, Xiaolei Xu, Ancheng Zheng, Weina Wang, Li Mei, Yue Chen, Shasha Sun, Liujun Jiang, Yutao Wu, Yijiang Zhou, Min Zheng, Qishan Chen – 12 March 2021

Physiologic Reserve Assessment and Application in Clinical and Research Settings in Liver Transplantation

Rahima A. Bhanji, Kymberly D. Watt – 12 March 2021 – Physiologic reserve is an important prognostic indicator. Because of its complexity, no single test can measure an individual’s physiologic reserve. Frailty is the phenotypic expression of decreased reserve and portends poor prognosis. Both subjective and objective tools have been used to measure one or more components of physiologic reserve. Most of these tools appear to predict pretransplant mortality, but only some predict posttransplant survival.

Identification of Quantifiable Predictors of Relapse in Patients with Alcohol‐Associated Liver Disease

Nicole T. Shen, Alyson Kaplan, Khalid Fahoum, Elora Basu, Akhil Shenoy, Nabeel Wahid, Amanda Ivatorov, Joseph Pisa, Annaheta Salajegheh, Enad Dawod, Russell Rosenblatt, Brett Fortune, Monika Safford, Robert S. Brown – 12 March 2021 – Abstinence in patients with alcohol‐associated liver disease (ALD) reduces mortality. Most predictors of relapse are not quantifiable, preventing objective analysis of relapse risk and targeted intervention to improve clinical outcomes.

Pathogenesis, MicroRNA‐122 Gene‐Regulation, and Protective Immune Responses After Acute Equine Hepacivirus Infection

Joy E. Tomlinson, Raphael Wolfisberg, Ulrik Fahnøe, Roosheel S. Patel, Sheetal Trivedi, Arvind Kumar, Himanshu Sharma, Louise Nielsen, Sean P. McDonough, Jens Bukh, Bud C. Tennant, Amit Kapoor, Brad R. Rosenberg, Charles M. Rice, Thomas J. Divers, Gerlinde R. Van de Walle, Troels K.H. Scheel – 12 March 2021

Outcome of COVID‐19 in Patients With Autoimmune Hepatitis: An International Multicenter Study

Cumali Efe, Renumathy Dhanasekaran, Craig Lammert, Berat Ebik, Fatima Higuera‐de la Tijera, Costica Aloman, Ali Rıza Calışkan, Mirta Peralta, Alessio Gerussi, Hatef Massoumi, Andreea M. Catana, Murat Torgutalp, Tugrul Purnak, Cristina Rigamonti, Andres Jose Gomez Aldana, Nidah Khakoo, Hüseyin Kacmaz, Leyla Nazal, Shalom Frager, Nurhan Demir, Kader Irak, Zeynep Melekoğlu Ellik, Yasemin Balaban, Kadri Atay, Fatih Eren, Laura Cristoferi, Ersin Batıbay, Álvaro Urzua, Romee Snijders, Murat Kıyıcı, Murat Akyıldız, Nazım Ekin, Rotonya M.

A Methodology to Generate Longitudinally Updated Acute‐On‐Chronic Liver Failure Prognostication Scores From Electronic Health Record Data

Jin Ge, Nader Najafi, Wendi Zhao, Ma Somsouk, Margaret Fang, Jennifer C. Lai – 11 March 2021 – Queries of electronic health record (EHR) data repositories allow for automated data collection. These techniques have not been used in hepatology due to the inability to capture hepatic encephalopathy (HE) grades, which are inputs for acute‐on‐chronic liver failure (ACLF) models. Here, we describe a methodology to use EHR data to calculate rolling ACLF scores. We examined 239 patient admissions with end‐stage liver disease from July 2014 to June 2019.

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