Sulfatase 2 (SULF2) Monoclonal Antibody 5D5 Suppresses Human Cholangiocarcinoma Xenograft Growth Through Regulation of a SULF2–Platelet‐Derived Growth Factor Receptor Beta–Yes‐Associated Protein Signaling Axis

Xin Luo, Nellie A. Campbell, Li He, Daniel R. O'Brien, Mark S. Singer, Hassan Lemjabbar‐Alaoui, Keun Soo Ahn, Rory Smoot, Michael S. Torbenson, Steven D. Rosen, Lewis R. Roberts – 17 March 2021

Analysis and Validation of Human Targets and Treatments Using a Hepatocellular Carcinoma–Immune Humanized Mouse Model

Yue Zhao, Jiaxu Wang, Wai Nam Liu, Shin Yie Fong, Timothy Wai Ho Shuen, Min Liu, Sarah Harden, Sue Yee Tan, Jia Ying Cheng, Wilson Wei Sheng Tan, Jerry Kok Yen Chan, Cheng Ean Chee, Guan Huei Lee, Han Chong Toh, Seng Gee Lim, Yue Wan, Qingfeng Chen – 17 March 2021

The Impact of the 2017 Kidney Allocation Policy Change on Simultaneous Liver‐Kidney Utilization and Outcomes

Mariya L. Samoylova, Kara Wegermann, Brian I. Shaw, Samuel J. Kesseli, Sandra Au, Christine Park, Samantha E. Halpern, Scott Sanoff, Andrew S. Barbas, Yuval A. Patel, Debra L. Sudan, Carl Berg, Lisa M. McElroy – 17 March 2021 – Historically in the United States, kidneys for simultaneous liver‐kidney transplantation (SLKT) candidates were allocated with livers, prioritizing SLKT recipients over much of the kidney waiting list. A 2017 change in policy delineated renal function criteria for SLKT and implemented a safety net for kidney‐after‐liver transplantation.

Black Race Is Associated With Higher Rates of Early‐Onset End‐Stage Renal Disease and Increased Mortality Following Liver Transplantation

Meagan Alvarado, Douglas E. Schaubel, K. Rajender Reddy, Therese Bittermann – 17 March 2021 – Black race is a risk factor for end‐stage renal disease (ESRD). Racial disparities in the risks of early and long‐term renal complications after liver transplantation (LT) have not been systematically studied. This study evaluated racial differences in the natural history of acute and chronic renal insufficiency after LT. This was a retrospective single‐center cohort study of 763 non‐Hispanic White and 181 Black LT recipients between 2008 and 2017.

Black Race Is Associated With Higher Rates of Early‐Onset End‐Stage Renal Disease and Increased Mortality Following Liver Transplantation

Meagan Alvarado, Douglas E. Schaubel, K. Rajender Reddy, Therese Bittermann – 17 March 2021 – Black race is a risk factor for end‐stage renal disease (ESRD). Racial disparities in the risks of early and long‐term renal complications after liver transplantation (LT) have not been systematically studied. This study evaluated racial differences in the natural history of acute and chronic renal insufficiency after LT. This was a retrospective single‐center cohort study of 763 non‐Hispanic White and 181 Black LT recipients between 2008 and 2017.

Hepatology Highlights

Hira Hanif, Mukarram Jamat Ali, Hao Wei Chen, Daryl T.Y. Lau, Gopanandan Parthasarathy, Robert E. Schwartz, Adebowale O. Bamidele, Nabeel A. Wahid, Russell Rosenblatt, David M. Salerno, Robert S. Brown, Adam Buckholz, Cesar Taborda, Joel Wedd, Alyson Kaplan, Brett E. Fortune, Nidhi Jalan‐Sakrikar – 16 March 2021

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