A Mouse Model of Cholangiocarcinoma Uncovers a Role for Tensin‐4 in Tumor Progression

Mickaël Di‐Luoffo, Sophie Pirenne, Thoueiba Saandi, Axelle Loriot, Claude Gérard, Nicolas Dauguet, Fátima Manzano‐Núñez, Natália Alves Souza Carvalhais, Florence Lamoline, Sabine Cordi, Katarzyna Konobrocka, Vitaline De Greef, Mina Komuta, Georg Halder, Patrick Jacquemin, Frédéric P. Lemaigre – 25 March 2021

Elective Surgery but not Transjugular Intrahepatic Portosystemic Shunt Precipitates Acute‐On‐Chronic Liver Failure

Johannes Chang, Avend Bamarni, Nina Böhling, Xin Zhou, Leah‐Marie Klein, Jonathan Meinke, Georg Daniel Duerr, Philipp Lingohr, Sven Wehner, Maximilian J. Brol, Jürgen K. Rockstroh, Jörg C. Kalff, Steffen Manekeller, Carsten Meyer, Ulrich Spengler, Christian Jansen, Vicente Arroyo, Christian P. Strassburg, Jonel Trebicka, Michael Praktiknjo – 25 March 2021 – Acute‐on‐chronic liver failure (ACLF) is a syndrome associated with organ failure and high short‐term mortality.

Impact of Metabolic Activity in Hepatocellular Carcinoma: Association With Immune Status and Vascular Formation

Shinji Itoh, Tomoharu Yoshizumi, Yoshiyuki Kitamura, Kyohei Yugawa, Norifumi Iseda, Tomonari Shimagaki, Yoshihiro Nagao, Takeo Toshima, Noboru Harada, Kenichi Kohashi, Shingo Baba, Kousei Ishigami, Yoshinao Oda, Masaki Mori – 25 March 2021 – We evaluated the prognostic value of fluorine‐18 fluorodeoxyglucose (18F‐FDG) positron emission tomography/computed tomography (PET/CT) in hepatocellular carcinoma (HCC). Their association with programmed death ligand 1 (PD‐L1) expression and vascular formation was further investigated.

Hepcidin Signaling in Health and Disease: Ironing Out the Details

Kris V. Kowdley, Eric M. Gochanour, Vinay Sundaram, Raj A. Shah, Priya Handa – 25 March 2021 – Hepcidin, a peptide hormone produced by hepatocytes, is the central regulator of systemic iron homeostasis through its interaction with ferroportin, the major cellular iron export protein. Hepcidin binding to ferroportin results in reduced iron export from macrophages and intestinal absorptive cells, leading to decreased serum iron levels. Hepcidin expression is influenced by several factors that include serum and liver iron stores, erythropoiesis, hypoxia, inflammation, and infection.

Genetic Determinants of Outcome in Intrahepatic Cholangiocarcinoma

Thomas Boerner, Esther Drill, Linda M. Pak, Bastien Nguyen, Carlie S. Sigel, Alexandre Doussot, Paul Shin, Debra A. Goldman, Mithat Gonen, Peter J. Allen, Vinod P. Balachandran, Andrea Cercek, James Harding, David B. Solit, Nikolaus Schultz, Ritika Kundra, Henry Walch, Michael I. D’Angelica, Ronald P. DeMatteo, Jeffrey Drebin, Nancy E. Kemeny, T. Peter Kingham, Amber L. Simpson, Jaclyn F. Hechtman, Efsevia Vakiani, Maeve A. Lowery, J.N.M. Ijzermans, S. Buettner, B. Groot Koerkamp, M. Doukas, Rohit Chandwani, William R. Jarnagin – 24 March 2021

Subscribe to