Vasor: Accurate prediction of variant effects for amino acid substitutions in multidrug resistance protein 3

Annika Behrendt, Pegah Golchin, Filip König, Daniel Mulnaes, Amelie Stalke, Carola Dröge, Verena Keitel, Holger Gohlke – 15 September 2022 – The phosphatidylcholine floppase multidrug resistance protein 3 (MDR3) is an essential hepatobiliary transport protein. MDR3 dysfunction is associated with various liver diseases, ranging from severe progressive familial intrahepatic cholestasis to transient forms of intrahepatic cholestasis of pregnancy and familial gallstone disease.

Practice patterns of the medical evaluation of living liver donors in the United States

Whitney E. Jackson, Alyson Kaplan, Jessica L. Saben, Michael S. Kriss, Jaime Cisek, Benjamin Samstein, AnnMarie Liapakis, Anjana A. Pillai, Robert S. Brown, Elizabeth A. Pomfret – 15 September 2022 – Living donor liver transplantation (LDLT) can help address the growing organ shortage in the United States, yet little is known about the current practice patterns in the medical evaluation of living liver donors. We conducted a 131‐question survey of all 53 active LDLT transplant programs in the United States to assess current LDLT practices. The response rate was 100%.

Combinatorial targeting of G‐protein‐coupled bile acid receptor 1 and cysteinyl leukotriene receptor 1 reveals a mechanistic role for bile acids and leukotrienes in drug‐induced liver injury

Michele Biagioli, Silvia Marchianò, Cristina Giorgio, Rosalinda Roselli, Martina Bordoni, Rachele Bellini, Bianca Fiorillo, Valentina Sepe, Bruno Catalanotti, Chiara Cassiano, Maria Chiara Monti, Eleonora Distrutti, Angela Zampella, Stefano Fiorucci – 14 September 2022

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