Hedgehog Signaling Modulates Interleukin‐33‐Dependent Extrahepatic Bile Duct Cell Proliferation in Mice

Nataliya Razumilava, Junya Shiota, Nureen H. Mohamad Zaki, Ramon Ocadiz‐Ruiz, Christine M. Cieslak, Kais Zakharia, Benjamin L. Allen, Gregory J. Gores, Linda C. Samuelson, Juanita L. Merchant – 11 December 2018 – Hedgehog (HH) signaling participates in hepatobiliary repair after injury and is activated in patients with cholangiopathies. Cholangiopathies are associated with bile duct (BD) hyperplasia, including expansion of peribiliary glands, the niche for biliary progenitor cells.

Endoscopic Ultrasound‐Guided Angiotherapy for Gastric Varices: A Single Center Experience

Tawfik Khoury, Muhammad Massarwa, Saleh Daher, Ariel A. Benson, Wadi Hazou, Eran Israeli, Harold Jacob, Julia Epstein, Rifaat Safadi – 10 December 2018 – There are limited efficacious therapeutic options for management of gastric variceal bleeding. Treatment modalities include transjugular intrahepatic portosystemic shunt, surgical shunts, and endoscopic interventions, including the recent advancement of endoscopic ultrasound (EUS)‐guided coiling.

Living Donor Liver Transplantation for Acute‐on‐Chronic Liver Failure

Sanjay Kumar Yadav, Neeraj Saraf, Narendra S. Choudhary, Jayant Kumar Sah, Sujeet Kumar Sah, Amit Rastogi, Prashant Bhangui, Sanjiv Saigal, Arvinder Singh Soin – 8 December 2018 – Acute‐on‐chronic liver failure (ACLF) is a syndrome characterized by acute decompensation of previously diagnosed or undiagnosed liver disease with organ failure(s) with high short‐term mortality. This study was conducted to report the outcomes of living donor liver transplantation (LDLT) in ACLF and assess the survival benefit of liver transplantation (LT) in these patients.

Fibrinolysis Shutdown Is Associated With Thrombotic and Hemorrhagic Complications and Poorer Outcomes After Liver Transplantation

Ramona Nicolau‐Raducu, Thiago Beduschi, Rodrigo Vianna, Christian Diez, Mahmoud Sleem, Bhavna P. Singh, Georgia Vasileiou, Yehuda Raveh – 7 December 2018 – Detrimental consequences of hypofibrinolysis, also known as fibrinolysis shutdown (FS), have recently arisen, and its significance in liver transplantation (LT) remains unknown. To fill this gap, this retrospective study included 166 adults who received transplants between 2016 and 2018 for whom baseline thromboelastography was available.

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