PTEN Down‐Regulation Promotes β‐Oxidation to Fuel Hypertrophic Liver Growth After Hepatectomy in Mice
Ekaterina Kachaylo, Christoph Tschuor, Nicolas Calo, Nathalie Borgeaud, Udo Ungethüm, Perparim Limani, Anne‐Christine Piguet, Jean‐Francois Dufour, Michelangelo Foti, Rolf Graf, Pierre A. Clavien, Bostjan Humar – 24 April 2017 – In regenerating liver, hepatocytes accumulate lipids before the major wave of parenchymal growth. This transient, regeneration‐associated steatosis (TRAS) is required for liver recovery, but its purpose is unclear.