The release of microRNA‐122 during liver preservation is associated with early allograft dysfunction and graft survival after transplantation

Jasmijn W. Selten, Cornelia J. Verhoeven, Veerle Heedfeld, Henk P. Roest, Jeroen de Jonge, Jacques Pirenne, Jos van Pelt, Jan. N. M. Ijzermans, Diethard Monbaliu, Luc J. W. van der Laan – 7 April 2017 – Early allograft dysfunction (EAD) after liver transplantation (LT) is associated with inferior graft survival. EAD is more prevalent in grafts from donation after circulatory death (DCD). However, accurate prediction of liver function remains difficult because of the lack of specific biomarkers.

Glyceraldehyde‐3‐phosphate dehydrogenase promotes liver tumorigenesis by modulating phosphoglycerate dehydrogenase

Shanshan Liu, Yu Sun, Ming Jiang, Yangkai Li, Ye Tian, Weili Xue, Ninghe Ding, Yue Sun, Cheng Cheng, Jianshuang Li, Xiaoping Miao, Xinran Liu, Ling Zheng, Kun Huang – 7 April 2017 – Up‐regulated glyceraldehyde‐3‐phosphate dehydrogenase (GAPDH) is observed in multiple cancers with unclear mechanism. Using GAPDH transgenic mouse and a mouse model of diethylnitrosamine‐induced hepatocellular carcinoma (HCC), here we show that GAPDH overexpression aggravated tumor development by activating cell proliferation and inflammation.

MicroRNA therapy inhibits hepatoblastoma growth in vivo by targeting β‐catenin and Wnt signaling

Emilie Indersie, Sarah Lesjean, Katarzyna B. Hooks, Francis Sagliocco, Tony Ernault, Stefano Cairo, Maria Merched‐Sauvage, Anne Rullier, Brigitte Le Bail, Sophie Taque, Michael Grotzer, Sophie Branchereau, Catherine Guettier, Monique Fabre, Laurence Brugières, Martin Hagedorn, Marie‐Annick Buendia, Christophe F. Grosset – 6 April 2017 – Hepatoblastoma (HBL) is the most common pediatric liver cancer. In this malignant neoplasm, beta‐catenin protein accumulates and increases Wnt signaling due to recurrent activating mutations in the catenin‐beta 1 (CTNNB1) gene.

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