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Thierry Gustot, Javier Fernandez, Elisabet Garcia, Marco Pavesi, Vicente Arroyo – 13 February 2017
On beyond staging and grading: Liver biopsy evaluation in a posttreatment world
David E. Kleiner – 13 February 2017
Left ventricular systolic function is associated with sympathetic nervous activity and markers of inflammation in cirrhosis
Raquel Yotti, Cristina Ripoll, Yolanda Benito, Maria Vega Catalina, Jaime Elízaga, Diego Rincón, Francisco Fernández‐Avilés, Javier Bermejo, Rafael Bañares – 13 February 2017 – An accurate evaluation of cardiac function in patients with cirrhosis remains a challenge. We used robust echocardiographic indices to characterize left ventricular (LV) systolic function and its relationship to activation of the sympathetic nervous system and inflammation in 59 patients with cirrhosis and 59 age‐matched controls.
Liver fibrosis scores predict liver disease mortality in the United States population
Aynur Unalp‐Arida, Constance E. Ruhl – 13 February 2017 – Fatty liver disease is common in the United States and worldwide due to changing lifestyles and can progress to fibrosis and cirrhosis contributing to premature death. We examined whether liver fibrosis scores were associated with increased overall and disease‐specific mortality in a United States population–based prospective survey with up to 23 years of linked‐mortality data. Data were analyzed from 14,841 viral hepatitis–negative adult participants in the third National Health and Nutrition Examination Survey, 1988‐1994.
Ammonia lowering reverses sarcopenia of cirrhosis by restoring skeletal muscle proteostasis
Avinash Kumar, Gangarao Davuluri, Rafaella Nascimento e Silva, Marielle P.K.J. Engelen, Gabrie A.M. Ten Have, Richard Prayson, Nicolaas E.P. Deutz, Srinivasan Dasarathy – 13 February 2017 – Sarcopenia or skeletal muscle loss is a frequent, potentially reversible complication in cirrhosis that adversely affects clinical outcomes. Hyperammonemia is a consistent abnormality in cirrhosis that results in impaired skeletal muscle protein synthesis and breakdown (proteostasis).
On beyond staging and grading: Liver biopsy evaluation in a posttreatment world
David E. Kleiner – 13 February 2017
Sodium taurocholate cotransporting polypeptide is the limiting host factor of hepatitis B virus infection in macaque and pig hepatocytes
Florian A. Lempp, Ellen Wiedtke, Bingqian Qu, Pierre Roques, Isabelle Chemin, Florian W. R. Vondran, Roger Le Grand, Dirk Grimm, Stephan Urban – 13 February 2017 – Infections with the human hepatitis B virus (HBV) and hepatitis D virus (HDV) depend on species‐specific host factors like the receptor human sodium taurocholate cotransporting polypeptide (hNTCP). Complementation of mouse hepatocytes with hNTCP confers susceptibility to HDV but not HBV, indicating the requirement of additional HBV‐specific factors.
Prioritization for liver transplantation: Reconsidering survival benefit
Andrew P. Keaveny, C. Burcin Taner – 13 February 2017
Patient understanding of hepatocellular carcinoma surveillance
Matthew A. Goldsworthy, Ian A. Rowe – 13 February 2017
Left ventricular systolic function is associated with sympathetic nervous activity and markers of inflammation in cirrhosis
Raquel Yotti, Cristina Ripoll, Yolanda Benito, Maria Vega Catalina, Jaime Elízaga, Diego Rincón, Francisco Fernández‐Avilés, Javier Bermejo, Rafael Bañares – 13 February 2017 – An accurate evaluation of cardiac function in patients with cirrhosis remains a challenge. We used robust echocardiographic indices to characterize left ventricular (LV) systolic function and its relationship to activation of the sympathetic nervous system and inflammation in 59 patients with cirrhosis and 59 age‐matched controls.