Environmental peer pressure: CD4+ T cell help in tolerance and transplantation

Dana Tedesco, Arash Grakoui – 19 September 2017 – The liver participates in a multitude of metabolic functions that are critical for sustaining human life. Despite constant encounters with antigenic‐rich intestinal blood, oxidative stress, and metabolic intermediates, there is no appreciable immune response. Interestingly, patients undergoing orthotopic liver transplantation benefit from a high rate of graft acceptance in comparison to other solid organ transplant recipients.

Biliary reconstructive techniques and associated anatomic variants in adult living donor liver transplantations: The adult‐to‐adult living donor liver transplantation cohort study experience

Talia B. Baker, Michael A. Zimmerman, Nathan P. Goodrich, Benjamin Samstein, Elizabeth A. Pomfret, James J. Pomposelli, Brenda W. Gillespie, Carl L. Berg, Jean C. Emond, Robert M. Merion – 19 September 2017 – Living donor liver transplantation (LDLT) is a technically demanding endeavor, requiring command of the complex anatomy of partial liver grafts. We examined the influence of anatomic variation and reconstruction techniques on surgical outcomes and graft survival in the 9‐center Adult‐to‐Adult Living Donor Liver Transplantation Cohort Study (A2ALL).

Effect of combined farnesoid X receptor agonist and angiotensin II type 1 receptor blocker on hepatic fibrosis

Tadashi Namisaki, Kei Moriya, Mitsuteru Kitade, Kosuke Takeda, Kosuke Kaji, Yasushi Okura, Naotaka Shimozato, Shinya Sato, Norihisa Nishimura, Kenichiro Seki, Hideto Kawaratani, Hiroaki Takaya, Yasuhiko Sawada, Takemi Akahane, Soichiro Saikawa, Keisuke Nakanishi, Takuya Kubo, Masanori Furukawa, Ryuichi Noguchi, Kiyoshi Asada, Koh Kitagawa, Takahiro Ozutsumi, Yuki Tsuji, Daisuke Kaya, Yukihisa Fujinaga, Hitoshi Yoshiji – 19 September 2017 – The farnesoid X receptor (FXR) agonist, a bile acid‐activated nuclear receptor, has been shown to improve the histologic features of nonalcoholic steatoh

MicroRNA‐506 promotes primary biliary cholangitis–like features in cholangiocytes and immune activation

Oihane Erice, Patricia Munoz‐Garrido, Javier Vaquero, Maria J. Perugorria, Maite G. Fernandez‐Barrena, Elena Saez, Alvaro Santos‐Laso, Ander Arbelaiz, Raul Jimenez‐Agüero, Joaquin Fernandez‐Irigoyen, Enrique Santamaria, Verónica Torrano, Arkaitz Carracedo, Meenakshisundaram Ananthanarayanan, Marco Marzioni, Jesus Prieto, Ulrich Beuers, Ronald P. Oude Elferink, Nicholas F. LaRusso, Luis Bujanda, Jose J.G. Marin, Jesus M.

Human leukocyte antigen variants and risk of hepatocellular carcinoma modified by hepatitis C virus genotypes: A genome‐wide association study

Mei‐Hsuan Lee, Yu‐Han Huang, Hsuan‐Yu Chen, Seik‐Soon Khor, Ya‐Hsuan Chang, Yu‐Ju Lin, Chin‐Lan Jen, Sheng‐Nan Lu, Hwai‐I Yang, Nao Nishida, Masaya Sugiyama, Masashi Mizokami, Yong Yuan, Gibert L'Italien, Katsushi Tokunaga, Chien‐Jen Chen, for the REVEAL‐HCV Cohort Study Group – 16 September 2017 – We conducted a genome‐wide association study to discover genetic variants associated with hepatitis C virus (HCV)–related hepatocellular carcinoma (HCC). We genotyped 502 HCC cases and 749 non‐HCC controls using the Axiom‐CHB genome‐wide array.

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