Matthew Goss, Jeffrey Reese, Michael Kueht, John M. Vierling, Ayse L. Mindikoglu, Norman L Sussman, Bruce Kaplan, R. Patrick Wood, Abbas A. Rana – 14 March 2017

Chad Walesky, Wolfram Goessling – 14 March 2017

Adianto Nugroho, Ok‐Kyung Kim, Kwang‐Woong Lee, Sanghee Song, Hyeyoung Kim, Suk Kyun Hong, Kyung Chul Yoon, Hyo‐Sin Kim, YoungRok Choi, Hae Won Lee, Nam‐Joon Yi, Kyung‐Suk Suh – 14 March 2017 – The process of evaluating potential donors in liver transplantation is important to ensure donor safety and provide optimal recipient outcomes. However, there has been no report about donor exclusion rates and reasons for such exclusion in Korea. In this study, we aimed to elucidate the outcomes of potential living liver donor evaluation in a major living donor liver transplantation center.

Marie Sinclair, Anthony Schelleman, Daljean Sandhu, Peter W. Angus – 13 March 2017 – We report a case of dramatic systemic inflammatory symptoms and biochemical signs of inflammation related to multiple hepatic adenomas that completely resolved after cessation of the oral contraceptive pill (OCP) and associated adenoma regression. This represents a case of dramatic symptoms that resolved after estrogen withdrawal alone. (Hepatology 2017;66:989–991).

Christine M. Hunt, Julie I. Papay, Vid Stanulovic, Arie Regev – 13 March 2017 – Drug‐induced hepatocellular injury is identified internationally by alanine aminotransferase (ALT) levels equal to or exceeding 5× the upper limit of normal (ULN) appearing within 3 months of drug initiation, after alternative causes are excluded. Upon withdrawing the suspect drug, ALT generally decrease by 50% or more. With drug readministration, a positive rechallenge has recently been defined by an ALT level of 3‐5× ULN or greater.

Marie Sinclair, Anthony Schelleman, Daljean Sandhu, Peter W. Angus – 13 March 2017 – We report a case of dramatic systemic inflammatory symptoms and biochemical signs of inflammation related to multiple hepatic adenomas that completely resolved after cessation of the oral contraceptive pill (OCP) and associated adenoma regression. This represents a case of dramatic symptoms that resolved after estrogen withdrawal alone. (Hepatology 2017;66:989–991).

Christine M. Hunt, Julie I. Papay, Vid Stanulovic, Arie Regev – 13 March 2017 – Drug‐induced hepatocellular injury is identified internationally by alanine aminotransferase (ALT) levels equal to or exceeding 5× the upper limit of normal (ULN) appearing within 3 months of drug initiation, after alternative causes are excluded. Upon withdrawing the suspect drug, ALT generally decrease by 50% or more. With drug readministration, a positive rechallenge has recently been defined by an ALT level of 3‐5× ULN or greater.

Fernando Bril, Kenneth Cusi – 13 March 2017

Yong He, Dechun Feng, Man Li, Yanhang Gao, Teresa Ramirez, Haixia Cao, Seung‐Jin Kim, Yang Yang, Yan Cai, Cynthia Ju, Hua Wang, Jun Li, Bin Gao – 13 March 2017 – Acetaminophen (APAP) overdose is a leading cause of acute liver failure worldwide, in which mitochondrial DNA (mtDNA) released by damaged hepatocytes activates neutrophils through binding of Toll‐like receptor 9 (TLR9), further aggravating liver injury. Here, we demonstrated that mtDNA/TLR9 also activates a negative feedback pathway through induction of microRNA‐223 (miR‐223) to limit neutrophil overactivation and liver injury.

Yingyun Yang, Ye Zhou, Jin Hou, Chunmei Bai, Zhenyang Li, Jia Fan, Irene O.L. Ng, Weiping Zhou, Huichuan Sun, Qiongzhu Dong, Joyce M.F. Lee, Chung‐Mau Lo, Kwan Man, Yun Yang, Nan Li, Guoshan Ding, Yizhi Yu, Xuetao Cao – 13 March 2017 – Adjuvant interferon‐α (IFN‐α) therapy is used to control certain types of cancer in clinics. For hepatocellular carcinoma (HCC), IFN‐α therapy is effective in only a subgroup of patients; therefore, identifying biomarkers to predict the response to IFN‐α therapy is of high significance and clinical utility.