Societal perspectives analysis for evaluating direct‐acting antiviral affordability while awaiting liver transplant
Xibei Liu, Yousif Elmofti, Catherine Kulaga, Brandon Gisi, Ji Won Yoo – 27 September 2017
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Aijaz Ahmed, Rachel Beckerman, Zobair M. Younossi – 27 September 2017
OATP1B1 and DAA treatment for hepatitis C in patients with hepatocellular carcinoma
Haithem Chtioui – 27 September 2017
Segregated hepatocyte proliferation and metabolic states within the regenerating mouse liver
Shilpi Minocha, Dominic Villeneuve, Leonor Rib, Catherine Moret, Nicolas Guex, Winship Herr – 26 September 2017 – Mammalian partial hepatectomy (PH) induces an orchestrated compensatory hyperplasia, or regeneration, in remaining tissue to restore liver mass; during this process, liver functions are maintained. We probed this process in mice with feeding‐ and light/dark‐entrained animals subjected to sham or PH surgery.
Progression of liver fibrosis is associated with non‐liver‐related mortality in patients with nonalcoholic fatty liver disease
Toshifumi Tada, Takashi Kumada, Hidenori Toyoda, Kazuyuki Mizuno, Yasuhiro Sone, Tomoyuki Akita, Junko Tanaka – 26 September 2017 – In patients with nonalcoholic fatty liver disease (NAFLD), prognosis and outcome, especially non‐liver‐related mortality, remain incompletely elucidated. We clarified the mortality from all causes in patients with NAFLD. A total of 4,073 patients with NAFLD diagnosed by ultrasonography were enrolled.
The ectonucleotidase ENTPD1/CD39 limits biliary injury and fibrosis in mouse models of sclerosing cholangitis
Zhen‐Wei Peng, Sonja Rothweiler, Guangyan Wei, Naoki Ikenaga, Susan B. Liu, Deanna Y. Sverdlov, Kahini A. Vaid, Maria Serena Longhi, Ming Kuang, Simon C. Robson, Yury V. Popov – 26 September 2017 – The pathogenesis of primary sclerosing cholangitis (PSC) and the mechanistic link to inflammatory bowel disease remain ill‐defined. Ectonucleoside triphosphate diphosphohydrolase‐1 (ENTPD1)/clusters of differentiation (CD) 39, the dominant purinergic ecto‐enzyme, modulates intestinal inflammation. Here, we have explored the role of CD39 in biliary injury and fibrosis.
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Andrea Schlegel, Irene Scalera, Marit Kalisvaart, Paolo Muiesan – 25 September 2017
Impact of donor age in donation after circulatory death liver transplantation: Is the cutoff “60” still of relevance?
Olivier Detry, Nicolas Meurisse, Pierre Honoré – 25 September 2017
Complexity and function of natural killer T cells with potential application to hepatic transplant survival
Randle Ware, Vipin Kumar – 25 September 2017 – One of the major innate‐like lymphocyte populations enriched in the liver consists of natural killer T (NKT) cells, which recognize self and foreign lipid antigens presented by the nonpolymorphic class I major histocompatibility complex–like molecule CD1d. NKT cells express natural killer cell markers as well as T cell receptors (TCRs) and can be classified into 2 categories: type I NKT cells use a semi‐invariant TCR, whereas type II NKT cells express diverse but still limited TCRs.
Salvage liver transplantation or repeat hepatectomy for recurrent hepatocellular carcinoma: An intent‐to‐treat analysis
Chetana Lim, Hiroji Shinkawa, Kiyoshi Hasegawa, Prashant Bhangui, Chady Salloum, Concepcion Gomez Gavara, Eylon Lahat, Kiyohiko Omichi, Junichi Arita, Yoshihiro Sakamoto, Philippe Compagnon, Cyrille Feray, Norihiro Kokudo, Daniel Azoulay – 25 September 2017 – The salvage liver transplantation (LT) strategy was conceived for initially resectable and transplantable hepatocellular carcinoma (HCC) to obviate upfront transplantation, with salvage LT in the case of recurrence. The longterm outcomes of a second resection for recurrent HCC have improved.