MicroRNA‐191 acts as a tumor promoter by modulating the TET1–p53 pathway in intrahepatic cholangiocarcinoma

Hao Li, Zun‐Qiang Zhou, Zhang‐Ru Yang, Da‐Nian Tong, Jiao Guan, Bao‐Jie Shi, Jia Nie, Xian‐Ting Ding, Bin Li, Guang‐Wen Zhou, Zheng‐Yun Zhang – 14 February 2017 – Current treatment of intrahepatic cholangiocarcinoma (ICC) remains ineffective because knowledge of ICC carcinogenesis is unclear. Increasing evidence suggests that microRNAs (miRNAs), including miR‐191, play an important role in tumorigenesis; but expression and biological functions of miR‐191 in ICC remain to be established. This study investigated the functions and underlying mechanisms of miR‐191 in ICC.

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