Liver transplant outcomes using ideal donation after circulatory death livers are superior to using older donation after brain death donor livers

Joseph R. Scalea, Robert R. Redfield, David P. Foley – 17 June 2016 – Multiple reports have demonstrated that liver transplantation following donation after circulatory death (DCD) is associated with poorer outcomes when compared with liver transplantation from donation after brain death (DBD) donors. We hypothesized that carefully selected, underutilized DCD livers recovered from younger donors have excellent outcomes.

Shared genetic effects between hepatic steatosis and fibrosis: A prospective twin study

Jeffrey Cui, Chi‐Hua Chen, Min‐Tzu Lo, Nicholas Schork, Ricki Bettencourt, Monica P. Gonzalez, Archana Bhatt, Jonathan Hooker, Katherine Shaffer, Karen E. Nelson, Michelle T. Long, David A. Brenner, Claude B. Sirlin, Rohit Loomba, for the Genetics of NAFLD in Twins Consortium – 17 June 2016 – Nonalcoholic fatty liver disease is associated with metabolic risk factors including hypertension and dyslipidemia and may progress to liver fibrosis. Studies have shown that hepatic steatosis and fibrosis are heritable, but whether they have a significant shared gene effect is unknown.

Treatment with Optifast reduces hepatic steatosis and increases candidacy rates for living donor liver transplantation

Adam Doyle, Oyedele Adeyi, Korosh Khalili, Sandra Fischer, Martin Dib, Nicolas Goldaracena, Jayne Dillon, David Grant, Mark Cattral, Ian McGilvray, Paul Greig, Anand Ghanekar, Leslie Lilly, Eberhard Renner, Gary Levy, Nazia Selzner – 17 June 2016

Inhibition of epoxyeicosatrienoic acid production in rats with cirrhosis has beneficial effects on portal hypertension by reducing splanchnic vasodilation

Marco Di Pascoli, Francesca Zampieri, Alberto Verardo, Paola Pesce, Cristian Turato, Paolo Angeli, David Sacerdoti, Massimo Bolognesi – 16 June 2016 – In cirrhosis, 11,12‐epoxyeicosatrienoic acid (EET) induces mesenteric arterial vasodilation, which contributes to the onset of portal hypertension. We evaluated the hemodynamic effects of in vivo inhibition of EET production in experimental cirrhosis. Sixteen control rats and 16 rats with carbon tetrachloride‐induced cirrhosis were studied.

Vertical sleeve gastrectomy activates GPBAR‐1/TGR5 to sustain weight loss, improve fatty liver, and remit insulin resistance in mice

Lili Ding, Kyle M. Sousa, Lihua Jin, Bingning Dong, Byung‐Wook Kim, Ricardo Ramirez, Zhenzhou Xiao, Ying Gu, Qiaoling Yang, Jie Wang, Donna Yu, Alessio Pigazzi, Dustin Schones, Li Yang, David Moore, Zhengtao Wang, Wendong Huang – 16 June 2016 – Vertical sleeve gastrectomy (VSG) is one of the most commonly performed clinical bariatric surgeries used for the remission of obesity and diabetes. However, the precise molecular mechanism by which VSG exerts its beneficial effects remains elusive.

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