Prognostic modeling in pediatric acute liver failure

Vandana Jain, Anil Dhawan – 24 June 2016 – Liver transplantation (LT) is the only proven treatment for pediatric acute liver failure (PALF). However, over a period of time, spontaneous native liver survival is increasingly reported, making us wonder if we are overtransplanting children with acute liver failure (ALF). An effective prognostic model for PALF would help direct appropriate organ allocation. Only patients who would die would undergo LT, and those who would spontaneously recover would avoid unnecessary LT.

Noninvasive imaging methods to determine severity of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis

William N. Hannah, Stephen A. Harrison – 24 June 2016 – Nonalcoholic fatty liver disease (NAFLD) is now the most common form of liver disease in developed countries, with an estimated prevalence of 20%‐30% and increasing to as high as 90% in diabetics. As the rates of NAFLD continue to rise in parallel with those of the obesity pandemic, it is increasingly important to differentiate those patients with the highest risk of progression to fibrosis and cirrhosis.

Recurrent primary sclerosing cholangitis in the Adult‐to‐Adult Living Donor Liver Transplantation Cohort Study: Comparison of risk factors between living and deceased donor recipients

Fredric D. Gordon, David S. Goldberg, Nathan P. Goodrich, Anna S. F. Lok, Elizabeth C. Verna, Nazia Selzner, R. Todd Stravitz, Robert M. Merion – 24 June 2016 – Primary sclerosing cholangitis (PSC) recurs in 15%‐25% of patients transplanted for PSC. In the United States, PSC transplant patients are more likely to receive an organ from a living donor (LD) than patients without PSC. Our aims were to (1) compare risk of PSC recurrence in LD versus deceased donor recipients and (2) identify risk factors for PSC recurrence.

Histological severity and clinical outcomes of nonalcoholic fatty liver disease in nonobese patients

Jonathan Chung‐Fai Leung, Thomson Chi‐Wang Loong, Jeremy Lok Wei, Grace Lai‐Hung Wong, Anthony Wing‐Hung Chan, Paul Cheung‐Lung Choi, Sally She‐Ting Shu, Angel Mei‐Ling Chim, Henry Lik‐Yuen Chan, Vincent Wai‐Sun Wong – 23 June 2016 – Although nonalcoholic fatty liver disease (NAFLD) is closely linked to obesity, around 10%‐20% of nonobese Americans and Asians still develop NAFLD. Data on this special group are limited. We therefore studied the severity and clinical outcomes of nonobese NAFLD patients. Consecutive NAFLD patients who underwent liver biopsy were prospectively recruited.

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