Serum microcystin levels positively linked with risk of hepatocellular carcinoma: A case‐control study in southwest China

Chuanfen Zheng, Hui Zeng, Hui Lin, Jia Wang, Xiaobin Feng, Zhiqun Qiu, Ji‐an Chen, Jiaohua Luo, Yang Luo, Yujing Huang, Lingqiao Wang, Wenyi Liu, Yao Tan, Anwei Xu, Yuan Yao, Weiqun Shu – 9 June 2017 – Microcystins have been reported to be carcinogenic by animal and cell experimentation, but there are no data on the linkage between serum microcystins and hepatocellular carcinoma (HCC) risk in humans.

Bone morphogenetic protein signaling governs biliary‐driven liver regeneration in zebrafish through tbx2b and id2a

Tae‐Young Choi, Mehwish Khaliq, Shinya Tsurusaki, Nikolay Ninov, Didier Y.R. Stainier, Minoru Tanaka, Donghun Shin – 9 June 2017 – Upon mild liver injury, new hepatocytes originate from preexisting hepatocytes. However, if hepatocyte proliferation is impaired, a manifestation of severe liver injury, biliary epithelial cells (BECs) contribute to new hepatocytes through BEC dedifferentiation into liver progenitor cells (LPCs), also termed oval cells or hepatoblast‐like cells (HB‐LCs), and subsequent differentiation into hepatocytes.

Significant association between FOXP3 gene polymorphism and steroid‐resistant acute rejection in living donor liver transplantation

Sapana Verma, Yuka Tanaka, Seiichi Shimizu, Naoki Tanimine, Hideki Ohdan – 8 June 2017 – Previous studies have found that preferential accumulation of regulatory T (Treg) cells in liver allografts during acute cellular rejection (ACR) is associated with less severe rejection, suggesting a role of Treg cells in preventing excessive progress of ACR. We investigated the impact of single nucleotide polymorphisms (SNPs) in the Forkhead box P3 (FOXP3) gene, a master regulator gene of Treg cells, on ACR severity in liver transplant (LT) recipients.

The 28‐year incidence of de novo malignancies after liver transplantation: A single‐center analysis of risk factors and mortality in 1616 patients

Sebastian Rademacher, Daniel Seehofer, Dennis Eurich, Wenzel Schoening, Ruth Neuhaus, Robert Oellinger, Timm Denecke, Andreas Pascher, Eckart Schott, Mariann Sinn, Peter Neuhaus, Johann Pratschke – 7 June 2017 – De novo malignancies (DNMs) are one of the leading causes of late mortality after liver transplantation (LT). We analyzed 1616 consecutive patients who underwent LT between 1988 and 2006 at our institution. All patients were prospectively observed over a study period of 28 years by our own outpatient clinic.

Hepatic artery reconstruction in living donor liver transplantation using surgical loupes: Achieving low rate of hepatic arterial thrombosis in 741 consecutive recipients—tips and tricks to overcome the poor hepatic arterial flow

Nonalcoholic fatty liver disease and the ongoing role of liver biopsy evaluation

Elizabeth M. Brunt – 7 June 2017 – Nonalcoholic fatty liver disease (NAFLD) is one of the most common underlying causes of chronically elevated liver tests and liver disease in adults and children worldwide and may be strongly suspected if not diagnosed by ever evolving and available serologic and imaging‐based noninvasive tests.

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