Carolin Ploeger, Nina Waldburger, Angelika Fraas, Benjamin Goeppert, Stefan Pusch, Kai Breuhahn, Xin Wei Wang, Peter Schirmacher, Stephanie Roessler – 16 June 2016 – Several chronic inflammatory liver diseases, e.g., chronic hepatitis B or C viral infection and steatohepatitis, have been shown to predispose to the development of hepatocellular carcinoma (HCC). In patients with chronic liver disease, interleukin‐6 (IL‐6) serum levels are elevated and increase even more when HCC develops.

Martin Wagner, Peter Fickert, Gernot Zollner – 16 June 2016

Chuhan Chung, Karl L. Insogna – 16 June 2016

Lili Ding, Kyle M. Sousa, Lihua Jin, Bingning Dong, Byung‐Wook Kim, Ricardo Ramirez, Zhenzhou Xiao, Ying Gu, Qiaoling Yang, Jie Wang, Donna Yu, Alessio Pigazzi, Dustin Schones, Li Yang, David Moore, Zhengtao Wang, Wendong Huang – 16 June 2016 – Vertical sleeve gastrectomy (VSG) is one of the most commonly performed clinical bariatric surgeries used for the remission of obesity and diabetes. However, the precise molecular mechanism by which VSG exerts its beneficial effects remains elusive.

Marco Di Pascoli, Francesca Zampieri, Alberto Verardo, Paola Pesce, Cristian Turato, Paolo Angeli, David Sacerdoti, Massimo Bolognesi – 16 June 2016 – In cirrhosis, 11,12‐epoxyeicosatrienoic acid (EET) induces mesenteric arterial vasodilation, which contributes to the onset of portal hypertension. We evaluated the hemodynamic effects of in vivo inhibition of EET production in experimental cirrhosis. Sixteen control rats and 16 rats with carbon tetrachloride‐induced cirrhosis were studied.

Sanjoy Roychowdhury, Rebecca L. McCullough, Carlos Sanz‐Garcia, Paramananda Saikia, Naim Alkhouri, Ammar Matloob, Katherine A. Pollard, Megan R. McMullen, Colleen M. Croniger, Laura E. Nagy – 15 June 2016 – Multiple pathways of programmed cell death are important in liver homeostasis. Hepatocyte death is associated with progression of nonalcoholic fatty liver disease, and inhibition of apoptosis partially protects against liver injury in response to a high‐fat diet (HFD).

Sandy Feng, Anthony J. Demetris, Katharine M. Spain, Sai Kanaparthi, Bryna E. Burrell, Udeme D. Ekong, Estella M. Alonso, Philip Rosenthal, Laurence A. Turka, David Ikle, Nadia K. Tchao – 15 June 2016 – Pediatric liver transplant recipients arguably have the most to gain and the most to lose from discontinuing immunosuppression (IS). Whereas IS undoubtedly exerts a cumulative toll, there is concern that insufficient or no IS may contribute to allograft deterioration.

Terence N. Bukong, Arvin Iracheta‐Vellve, Banishree Saha, Aditya Ambade, Abhishek Satishchandran, Benedek Gyongyosi, Patrick Lowe, Donna Catalano, Karen Kodys, Gyongyi Szabo – 15 June 2016 – The spectrum of alcoholic liver disease (ALD) is a major cause of mortality with limited therapies available. Because alcohol targets numerous signaling pathways in hepatocytes and in immune cells, the identification of a master regulatory target that modulates multiple signaling processes is attractive.

Heather L. Laskey, Nathan Schomaker, Kenneth W. Hung, Sumeet K. Asrani, Linda Jennings, Trevor L. Nydam, Jane Gralla, Alex Wiseman, Hugo R. Rosen, Scott W. Biggins – 15 June 2016 – Identifying which liver transplantation (LT) candidates with severe kidney injury will have a full recovery of renal function after liver transplantation alone (LTA) is difficult. Avoiding unnecessary simultaneous liver‐kidney transplantation (SLKT) can optimize the use of scarce kidney grafts. Incorrect predictions of spontaneous renal recovery after LTA can lead to increased morbidity and mortality.

Minjun Chen, Jürgen Borlak, Weida Tong – 15 June 2016 – Drug‐induced liver injury (DILI) is a major public health concern, and improving its prediction remains an unmet challenge. Recently, we reported the Rule‐of‐2 (RO2) and found lipophilicity (logP ≥3) and daily dose ≥100 mg of oral medications to be associated with significant risk for DILI; however, the RO2 failed to estimate grades of DILI severity.