Combined hepatocellular‐cholangiocarcinoma in a patient with Abernethy malformation and tetralogy of Fallot: A case report

Sofie Happaerts, Amélie Foucault, Jean Sébastien Billiard, Bich Nguyen, Franck Vandenbroucke‐Menu – 26 May 2016 – Abernethy malformation is a rare congenital anomaly of the portal vein where the portal blood bypasses the liver. We report the first case of a patient with Abernethy malformation and tetralogy of Fallot associated with nodular regenerative hyperplasia and focal nodular hyperplasia (FNH), which finally evolved to a giant hepatocellular‐cholangiocarcinoma (HCC‐CC) of the liver, successfully resected. (Hepatology 2016;64:1800‐1802)

Adipocyte‐specific overexpression of retinol‐binding protein 4 causes hepatic steatosis in mice

Seung‐Ah Lee, Jason J. Yuen, Hongfeng Jiang, Barbara B. Kahn, William S. Blaner – 26 May 2016 – There is considerable evidence that both retinoids and retinol‐binding protein 4 (RBP4) contribute to the development of liver disease. To understand the basis for this, we generated and studied transgenic mice that express human RBP4 (hRBP4) specifically in adipocytes. When fed a chow diet, these mice show an elevation in adipose total RBP4 (mouse RBP4 + hRBP4) protein levels.

Progressive accumulation of mutations in the hepatitis B virus genome and its impact on time to diagnosis of hepatocellular carcinoma

Feng‐Yu Sung, Chia‐Ying Lan, Chi‐Jung Huang, Chih‐Lin Lin, Chun‐Jen Liu, Pei‐Jer Chen, Shi‐Ming Lin, Ming‐Whei Yu – 26 May 2016 – To evaluate how hepatitis B virus (HBV) genetic variation affected progression from chronic carrier state to hepatocellular carcinoma (HCC), we analyzed HBV full‐length sequences in blood obtained <1‐20 years before diagnosis from 117 HCC cases and 118 controls nested in a cohort of 4,841 HBV carriers, for whom HBV genotypes B and C are predominant.

Hypoxia induces myeloid‐derived suppressor cell recruitment to hepatocellular carcinoma through chemokine (C‐C motif) ligand 26

David Kung‐Chun Chiu, Iris Ming‐Jing Xu, Robin Kit‐Ho Lai, Aki Pui‐Wah Tse, Larry Lai Wei, Hui‐Yu Koh, Lynna Lan Li, Derek Lee, Regina Cheuk‐Lam Lo, Chun‐Ming Wong, Irene Oi‐Lin Ng, Carmen Chak‐Lui Wong – 26 May 2016 – A population of stromal cells, myeloid‐derived suppressor cells (MDSCs), is present in tumors. Though studies have gradually revealed the protumorigenic functions of MDSCs, the molecular mechanisms guiding MDSC recruitment remain largely elusive.

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