Circulating let‐7 levels in plasma and extracellular vesicles correlate with hepatic fibrosis progression in chronic hepatitis C

Kentaro Matsuura, Valeria De Giorgi, Cathy Schechterly, Richard Y. Wang, Patrizia Farci, Yasuhito Tanaka, Harvey J. Alter – 26 May 2016 – The goal of this study was to determine whether an association exists between circulating microRNA (miRNA) levels and disease progression in chronic hepatitis C (CHC), whether plasma or extracellular vesicles (EVs) were optimal for miRNA measurement and their correlation with hepatic miRNA expression, and the mechanistic plausibility of this association. We studied 130 CHC patients prospectively followed over several decades.

Liver transplantation for children with acute liver failure associated with secondary hemophagocytic lymphohistiocytosis

Achiya Z. Amir, Simon C. Ling, Ahmed Naqvi, Sheila Weitzman, Annie Fecteau, David Grant, Anand Ghanekar, Mark Cattral, Nadya Nalli, Ernest Cutz, Binita Kamath, Nicola Jones, Maria Angelis, Vicky Ng, Yaron Avitzur – 23 May 2016 – Hemophagocytic lymphohistiocytosis (HLH) is a rare life‐threatening systemic disease, characterized by overwhelming stimulation of the immune system and categorized as primary or secondary types. Occasionally, acute liver failure (ALF) may dominate the clinical presentation.

The role of hepatitis E virus infection in adult Americans with acute liver failure

Robert John Fontana, Ronald E. Engle, Steven Scaglione, Victor Araya, Obaid Shaikh, Holly Tillman, Nahid Attar, Robert H. Purcell, William M. Lee, for the US Acute Liver Failure Study Group – 23 May 2016 – Acute hepatitis E virus (HEV) infection is a leading cause of acute liver failure (ALF) in many developing countries, yet rarely identified in Western countries. Given that antibody testing for HEV infection is not routinely obtained, we hypothesized that HEV‐related ALF might be present and unrecognized in North American ALF patients. Serum samples of 681 adults enrolled in the U.S.

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