Limei Liu, Chungang Liu, Qianzhen Zhang, Junjie Shen, Heng Zhang, Juanjuan Shan, Guangjie Duan, Deyu Guo, Xuejiao Chen, Jiamin Cheng, Yanmin Xu, Zhi Yang, Chao Yao, Maode Lai, Cheng Qian – 16 June 2016 – Hepatocellular carcinoma (HCC) is a highly aggressive liver tumor containing cancer stem cells (CSCs), which participate in tumor invasion, therapeutic resistance, and tumor relapse leading to poor outcome and limited therapeutic options. Histone deacetylatase sirtuin 1 (SIRT1) has been shown to be up‐regulated in human cancers; however, its role in liver CSCs is unknown.

Martin K. Thomsen, Ramya Nandakumar, Daniela Stadler, Antje Malo, Roser Marin Valls, Fan Wang, Line S. Reinert, Frederik Dagnæs‐Hansen, Anne Kruse Hollensen, Jacob Giehm Mikkelsen, Ulrike Protzer, Søren R. Paludan – 16 June 2016 – Hepatitis B virus (HBV) is a major human pathogen, and about one third of the global population will be exposed to the virus in their lifetime. HBV infects hepatocytes, where it replicates its DNA and infection can lead to acute and chronic hepatitis with a high risk of liver cirrhosis and hepatocellular carcinoma.

Lili Ding, Kyle M. Sousa, Lihua Jin, Bingning Dong, Byung‐Wook Kim, Ricardo Ramirez, Zhenzhou Xiao, Ying Gu, Qiaoling Yang, Jie Wang, Donna Yu, Alessio Pigazzi, Dustin Schones, Li Yang, David Moore, Zhengtao Wang, Wendong Huang – 16 June 2016 – Vertical sleeve gastrectomy (VSG) is one of the most commonly performed clinical bariatric surgeries used for the remission of obesity and diabetes. However, the precise molecular mechanism by which VSG exerts its beneficial effects remains elusive.

Carolin Ploeger, Nina Waldburger, Angelika Fraas, Benjamin Goeppert, Stefan Pusch, Kai Breuhahn, Xin Wei Wang, Peter Schirmacher, Stephanie Roessler – 16 June 2016 – Several chronic inflammatory liver diseases, e.g., chronic hepatitis B or C viral infection and steatohepatitis, have been shown to predispose to the development of hepatocellular carcinoma (HCC). In patients with chronic liver disease, interleukin‐6 (IL‐6) serum levels are elevated and increase even more when HCC develops.

Martin Wagner, Peter Fickert, Gernot Zollner – 16 June 2016

Chuhan Chung, Karl L. Insogna – 16 June 2016

Lili Ding, Kyle M. Sousa, Lihua Jin, Bingning Dong, Byung‐Wook Kim, Ricardo Ramirez, Zhenzhou Xiao, Ying Gu, Qiaoling Yang, Jie Wang, Donna Yu, Alessio Pigazzi, Dustin Schones, Li Yang, David Moore, Zhengtao Wang, Wendong Huang – 16 June 2016 – Vertical sleeve gastrectomy (VSG) is one of the most commonly performed clinical bariatric surgeries used for the remission of obesity and diabetes. However, the precise molecular mechanism by which VSG exerts its beneficial effects remains elusive.

Marco Di Pascoli, Francesca Zampieri, Alberto Verardo, Paola Pesce, Cristian Turato, Paolo Angeli, David Sacerdoti, Massimo Bolognesi – 16 June 2016 – In cirrhosis, 11,12‐epoxyeicosatrienoic acid (EET) induces mesenteric arterial vasodilation, which contributes to the onset of portal hypertension. We evaluated the hemodynamic effects of in vivo inhibition of EET production in experimental cirrhosis. Sixteen control rats and 16 rats with carbon tetrachloride‐induced cirrhosis were studied.

Sanjoy Roychowdhury, Rebecca L. McCullough, Carlos Sanz‐Garcia, Paramananda Saikia, Naim Alkhouri, Ammar Matloob, Katherine A. Pollard, Megan R. McMullen, Colleen M. Croniger, Laura E. Nagy – 15 June 2016 – Multiple pathways of programmed cell death are important in liver homeostasis. Hepatocyte death is associated with progression of nonalcoholic fatty liver disease, and inhibition of apoptosis partially protects against liver injury in response to a high‐fat diet (HFD).

Sandy Feng, Anthony J. Demetris, Katharine M. Spain, Sai Kanaparthi, Bryna E. Burrell, Udeme D. Ekong, Estella M. Alonso, Philip Rosenthal, Laurence A. Turka, David Ikle, Nadia K. Tchao – 15 June 2016 – Pediatric liver transplant recipients arguably have the most to gain and the most to lose from discontinuing immunosuppression (IS). Whereas IS undoubtedly exerts a cumulative toll, there is concern that insufficient or no IS may contribute to allograft deterioration.