A Model to predict severity of drug‐induced liver injury in humans

Minjun Chen, Jürgen Borlak, Weida Tong – 15 June 2016 – Drug‐induced liver injury (DILI) is a major public health concern, and improving its prediction remains an unmet challenge. Recently, we reported the Rule‐of‐2 (RO2) and found lipophilicity (logP ≥3) and daily dose ≥100 mg of oral medications to be associated with significant risk for DILI; however, the RO2 failed to estimate grades of DILI severity.

Predicting renal recovery after liver transplant with severe pretransplant subacute kidney injury: The impact of warm ischemia time

Heather L. Laskey, Nathan Schomaker, Kenneth W. Hung, Sumeet K. Asrani, Linda Jennings, Trevor L. Nydam, Jane Gralla, Alex Wiseman, Hugo R. Rosen, Scott W. Biggins – 15 June 2016 – Identifying which liver transplantation (LT) candidates with severe kidney injury will have a full recovery of renal function after liver transplantation alone (LTA) is difficult. Avoiding unnecessary simultaneous liver‐kidney transplantation (SLKT) can optimize the use of scarce kidney grafts. Incorrect predictions of spontaneous renal recovery after LTA can lead to increased morbidity and mortality.

Inhibition of spleen tyrosine kinase activation ameliorates inflammation, cell death, and steatosis in alcoholic liver disease

Terence N. Bukong, Arvin Iracheta‐Vellve, Banishree Saha, Aditya Ambade, Abhishek Satishchandran, Benedek Gyongyosi, Patrick Lowe, Donna Catalano, Karen Kodys, Gyongyi Szabo – 15 June 2016 – The spectrum of alcoholic liver disease (ALD) is a major cause of mortality with limited therapies available. Because alcohol targets numerous signaling pathways in hepatocytes and in immune cells, the identification of a master regulatory target that modulates multiple signaling processes is attractive.

Five‐year histological and serological follow‐up of operationally tolerant pediatric liver transplant recipients enrolled in WISP‐R

Sandy Feng, Anthony J. Demetris, Katharine M. Spain, Sai Kanaparthi, Bryna E. Burrell, Udeme D. Ekong, Estella M. Alonso, Philip Rosenthal, Laurence A. Turka, David Ikle, Nadia K. Tchao – 15 June 2016 – Pediatric liver transplant recipients arguably have the most to gain and the most to lose from discontinuing immunosuppression (IS). Whereas IS undoubtedly exerts a cumulative toll, there is concern that insufficient or no IS may contribute to allograft deterioration.

Receptor interacting protein 3 protects mice from high‐fat diet‐induced liver injury

Sanjoy Roychowdhury, Rebecca L. McCullough, Carlos Sanz‐Garcia, Paramananda Saikia, Naim Alkhouri, Ammar Matloob, Katherine A. Pollard, Megan R. McMullen, Colleen M. Croniger, Laura E. Nagy – 15 June 2016 – Multiple pathways of programmed cell death are important in liver homeostasis. Hepatocyte death is associated with progression of nonalcoholic fatty liver disease, and inhibition of apoptosis partially protects against liver injury in response to a high‐fat diet (HFD).

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Eduardo Vilar‐Gomez, Luis Calzadilla‐Bertot, Scott L. Friedman, Manuel Romero‐Gomez – 10 June 2016

Excretion of infectious hepatitis E virus into milk in cows imposes high risks of zoonosis

Fen Huang, Yunlong Li, Wenhai Yu, Shenrong Jing, Jue Wang, Feiyan Long, Zhanlong He, Chenchen Yang, Yanhong Bi, Wentao Cao, Chengbo Liu, Xiuguo Hua, Qiuwei Pan – 10 June 2016 – Hepatitis E virus (HEV) represents the main cause of acute hepatitis worldwide. HEV infection in immunocompromised patients involves a high risk for the development of chronic hepatitis. Because HEV is recognized as a zoonotic pathogen, it is currently believed that swine is the primary reservoir.

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