A highly specific and sensitive hepatitis C virus antigen enzyme immunoassay for One‐step diagnosis of viremic hepatitis C virus infection

Ke‐Qin Hu, Wei Cui – 6 June 2016 – The current standard in diagnosing hepatitis C virus (HCV) infection requires two sequential steps: anti‐HCV test to screen, followed by HCV RNA reverse‐transcription polymerase chain reaction to confirm viremic HCV (V‐HCV) infection. HCV core antigen tests provided potential for possible one‐step diagnosis. However, low sensitivity and specificity limit their clinical utility.

Recurrence of autoimmune liver disease and inflammatory bowel disease after pediatric liver transplantation

Rodrigo Liberal, Diego Vergani, Giorgina Mieli‐Vergani – 3 June 2016 – Approximately 10% of children with autoimmune hepatitis (AIH) and 30% of those with sclerosing cholangitis (SC) require liver transplantation (LT). LT is indicated in patients who present with fulminant hepatic failure (ie, with encephalopathy) and in those who develop end‐stage liver disease despite treatment. After LT, recurrent AIH is reported in approximately 30% of patients and recurrent SC in up to 50%.

Splenectomy is not indicated in living donor liver transplantation

Kyoji Ito, Nobuhisa Akamatsu, Akihiko Ichida, Daisuke Ito, Junichi Kaneko, Junichi Arita, Yoshihiro Sakamoto, Kiyoshi Hasegawa, Norihiro Kokudo – 2 June 2016 – Simultaneous splenectomy (SPX) is preferentially performed in living donor liver transplantation (LDLT) to modulate portal flow; increase postoperative platelet count, especially among those with hepatitis C virus (HCV) infection; and modulate the immunologic status in ABO‐incompatible cases. The negative effects of the procedure, however, are not well established.

Detection of hepatitis b virus DNA in the blood of a stem cell donor after granulocyte colony‐stimulating factor treatment

Michael Punzel, Patrick Medd, Hannah Hunter, Richard Cunningham, Bryson Pottinger, Bernd Burde, Marek Widera, Annegret Quade, Gerhard Ehninger, Anna Kozlova, Helmuth Schmidt, Karin Buhrmann, Christian G. Schüttler, Dieter Glebe, Annelies Billen, Alexander H. Schmidt, Thilo Mengling, Jens Verheyen – 30 May 2016

Detection of hepatitis b virus DNA in the blood of a stem cell donor after granulocyte colony‐stimulating factor treatment

Michael Punzel, Patrick Medd, Hannah Hunter, Richard Cunningham, Bryson Pottinger, Bernd Burde, Marek Widera, Annegret Quade, Gerhard Ehninger, Anna Kozlova, Helmuth Schmidt, Karin Buhrmann, Christian G. Schüttler, Dieter Glebe, Annelies Billen, Alexander H. Schmidt, Thilo Mengling, Jens Verheyen – 30 May 2016

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I. Lisanne Holster, Eric T.T.L. Tjwa, Adriaan Moelker, Ernst J. Kuipers, Henk R. van Buuren – 30 May 2016

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