New classification of liver biopsy assessment for fibrosis in chronic hepatitis B patients before and after treatment

Yameng Sun, Jialing Zhou, Lin Wang, Xiaoning Wu, Yongpeng Chen, Hongxin Piao, Lungen Lu, Wei Jiang, Youqing Xu, Bo Feng, Yuemin Nan, Wen Xie, Guofeng Chen, Huanwei Zheng, Hai Li, Huiguo Ding, Hui Liu, Fudong Lv, Chen Shao, Tailing Wang, Xiaojuan Ou, Bingqiong Wang, Shuyan Chen, Aileen Wee, Neil D. Theise, Hong You, Jidong Jia – 27 December 2016 – Liver fibrosis is the net result of dynamic changes between fibrogenesis and fibrolysis. Evidence has shown that antiviral therapy can reverse liver fibrosis or even early cirrhosis caused by hepatitis B virus.

Hepatitis B reactivation in occult viral carriers undergoing hematopoietic stem cell transplantation: A prospective study

Wai‐Kay Seto, Thomas Sau‐Yan Chan, Yu‐Yan Hwang, Danny Ka‐Ho Wong, James Fung, Kevin Sze‐Hang Liu, Harinder Gill, Yuk‐Fai Lam, Eric H.Y. Lau, Ka‐Shing Cheung, Albert K.W. Lie, Ching‐Lung Lai, Yok‐Lam Kwong, Man‐Fung Yuen – 27 December 2016 – Hepatitis B virus (HBV) reactivation in hepatitis B surface antigen (HBsAg)–negative, antibody to hepatitis B core antigen (anti‐HBc)–positive patients after allogeneic hematopoietic stem cell transplantation (HSCT) has not been prospectively studied.

Is size the only determinant of delayed abdominal closure in pediatric liver transplant?

Shirin Elizabeth Khorsandi, Arthur William Raven Day, Miriam Cortes, Akash Deep, Anil Dhawan, Hector Vilca‐Melendez, Nigel Heaton – 27 December 2016 – The aim was to determine the factors associated with the use of delayed abdominal closure in pediatric liver transplantation (LT) and whether this affected outcome. From a prospectively maintained database, transplants performed in children (≤18 years) were identified (October 2010 to March 2015). Primary abdominal closure was defined as mass closure performed at time of transplant.

Longterm prognosis of combined hepatocellular carcinoma‐cholangiocarcinoma following liver transplantation and resection

Dong‐Hwan Jung, Shin Hwang, Gi‐Won Song, Chul‐Soo Ahn, Deok‐Bog Moon, Ki‐Hun Kim, Tae‐Yong Ha, Gil‐Chun Park, Seung‐Mo Hong, Wan‐Jun Kim, Woo‐Hyoung Kang, Seok‐Hwan Kim, Eun Sil Yu, Sung‐Gyu Lee – 27 December 2016 – Combined hepatocellular carcinoma–cholangiocarcinoma (cHCC‐CC) is a rare disease. We investigated the clinicopathological features of cHCC‐CC and compared the longterm outcomes following liver transplantation (LT) and hepatic resection (HR). We identified 32 LT patients with cHCC‐CC through an institutional database search.

Comparison of longterm outcomes and quality of life in recipients of donation after cardiac death liver grafts with a propensity‐matched cohort

Kristopher P. Croome, David D. Lee, Dana K. Perry, Justin M. Burns, Justin H. Nguyen, Andrew P. Keaveny, C. Burcin Taner – 27 December 2016 – The use of liver grafts from donation after cardiac death (DCD) has been limited due to the increased rate of graft failure, mostly related to ischemic cholangiopathy (IC). It is our hypothesis that longterm outcomes and quality of life (QOL) similar to patients undergoing liver transplantation (LT) with donation after brain death (DBD) can be achieved.

A practical approach to nutritional screening and assessment in cirrhosis

Puneeta Tandon, Maitreyi Raman, Marina Mourtzakis, Manuela Merli – 27 December 2016 – Malnutrition is one of the most common complications of cirrhosis, associated with an increased risk of morbidity and mortality. As a potentially modifiable condition, it is of particular importance to identify malnourished patients so that nutritional therapy can be instituted. Nutrition screening and assessment are infrequently performed in patients with cirrhosis.

Defects in myosin VB are associated with a spectrum of previously undiagnosed low γ‐glutamyltransferase cholestasis

Yi‐Ling Qiu, Jing‐Yu Gong, Jia‐Yan Feng, Ren‐Xue Wang, Jun Han, Teng Liu, Yi Lu, Li‐Ting Li, Mei‐Hong Zhang, Jonathan A. Sheps, Neng‐Li Wang, Yan‐Yan Yan, Jia‐Qi Li, Lian Chen, Christoph H. Borchers, Bence Sipos, A.S. Knisely, Victor Ling, Qing‐He Xing, Jian‐She Wang – 27 December 2016 – Hereditary cholestasis in childhood and infancy with normal serum gamma‐glutamyltransferase (GGT) activity is linked to several genes. Many patients, however, remain genetically undiagnosed.

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