This meet-up fosters meaningful interaction between the patient community with health care clinicians focused on those affected by primary biliary cholangitis (PBC).

Join the experts in this session to learn about highly relevant, clinical hot topic issues for hepatitis B management in 2025. Topics include: quantitative HBsAg testing in clinical practice; HCC risk calculators; noninvasive testing for hepatic fibrosis; and metabolic dysfunction-associated steatotic liver disease in patients with HBV infection. 

Cell stress can lead to proliferative arrest (senescence), which can accelerate disease progression through a variety of mechanisms. Subject matter experts explore triggers and pathways that convert cells to a senescent, secretory phenotype. Session topics include: characteristics of cell senescence; the role of cellular senescence in the progression of chronic liver injury; types of cell populations affected (hepatocytes, cholangiocytes, hepatic stellate cells, and others); beneficial and harmful effects of cell senescence; molecular mechanisms; and potential therapeutic strategies. 

Explore the transformative role of artificial intelligence (AI) in pediatric hepatology and liver transplantation, highlighting how AI innovations are reshaping early diagnosis, risk stratification, and personalized treatment strategies for pediatric liver diseases. Experts review AI-driven advancements in noninvasive diagnostics, predictive analytics for disease progression, and optimizing donor-recipient matching in liver transplantation. Speakers also address the role of AI in improving posttransplant care, including graft survival prediction and early detection of complications. Emphasizing practical applications, ongoing challenges, and ethical considerations, this session demonstrates how AI can enhance decision-making, improve outcomes, and pave the way for precision medicine in pediatric liver care.

Presenters explore commonly encountered clinical scenarios where practice patterns are variable and consensus is often lacking on the appropriate application of guidelines. Experts offer insights from real-world experience and large-scale data to generate consensus on the best clinical practices in the following scenarios: applying portal hypertension guidance to individual patients; improving surgical risk stratification; rethinking spontaneous bacterial peritonitis prophylaxis; and optimizing use of albumin and terlipressin.

Topic experts discuss the risk of DILI and phenotypes of presentation from children to the elderly. Presenters review emerging and novel therapies associated with DILI, provide an update on blood-based biomarkers of DILI, and highlight research priorities to address knowledge gaps in this constantly evolving space.

This focused session brings together experienced hepatology researchers to share insights on the critical elements of building a successful research career, whether pursuing a clinician-investigator or academic researcher path. Through 3 comprehensive lectures and an interactive panel discussion, participants learn essential strategies for establishing mentorship relationships, conducting impactful clinical research, and navigating the academic timeline. For clinicians maintaining busy practices, speakers address practical approaches to integrating research activities within clinical responsibilities, including strategies for protected research time and efficient study execution. For those pursuing dedicated academic research careers, the session covers establishing independent research programs, securing sustained funding, and building research teams. The session features leading experts who share their personal experiences and practical advice from both career paths, followed by an open forum where attendees can engage directly with speakers to address specific questions about research career development in hepatology.

Join your SIG Meet-Up, where you can connect with professionals who share your research and clinical interests! Enjoy light snacks, fun games, and great conversations in a relaxed, informal setting—perfect for networking and building new connections.

• Hepatotoxicity 
• Hepatitis B/Delta 
• Pediatric Liver Disease 
• Acute on Chronic Liver Failure 
• Liver Cancer 

Join us at the Members Reception, an exclusive members-only event designed to celebrate and appreciate our dedicated AASLD members. This evening gathering provides an excellent opportunity to reconnect with fellow members, share your experiences, and engage with AASLD leadership.

Sponsored by: Madrigal Pharmaceuticals and Mirum Pharmaceuticals
 

The Acute-on-Chronic Liver Failure (ACLF) Special Interest Group presents current clinical and research gaps pertaining to the study and care of patients with ACLF. The introductory presentation prompts further discussion on 4 distinct topics focused on: (1) outstanding care gaps in critically ill patients with ACLF; (2) the role of novel statistical methods in ACLF diagnosis and prognostication; (3) designing clinical studies in ACLF; and (4) pathways to therapeutic advancements in ACLF. The session concludes with a panel discussion.